Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer

Figure 3

Interindividual variations of TIGIT (green) and PD-1 (red) in 10 patients (P1-10) each with Hashimoto thyroiditis and sarcoidosis; two patients (P1 and P2) each with lichen sclerosus, IgG4 pancreatitis, and rheumatoid arthritis of (a) CD4⁺ helper T cells, (b) CD8⁺ cytotoxic T cells, and (c) FOXP3⁺ regulatory T cells. Relative expression refers to the fluorescence measurement in the tonsil germinal centre periphery (Ref. Gc. To.) set to 100%. The black bar shows the TIGIT : PD-1 expression ratio. In.: interfollicular area; Gc.: germinal centre; Gra.: granuloma; Interg.: intergranuloma; Lymphocytic in.: lymphocytic infiltration; To: tonsil; ; ; ; [n.s.]: not significant ().

(a)

(b)

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