Research Article
Polymorphisms -455G/A and -148C/T and Fibrinogen Plasmatic Level as Risk Markers of Coronary Disease and Major Adverse Cardiovascular Events
Table 2
Fibrinogen genotypes and alleles.
| | Genotype | Controls
(%) | SCD
(%) | UCD
(%) | value |
| | -455 Fg | | | | 0.016 | | G/G | 67 (82.7) | 40 (58.8) | 30 (60) | | G/A | 12 (14.8) | 26 (38.2) | 20 (40) | | A/A | 2 (2.5) | 2 (3.0) | 0 (0) | | +1689 Fg | | | | 0.932 | | T/T | 55 (67.9) | 44 (64.7) | 30 (60) | | G/T | 25 (30.9) | 23 (33.8) | 19 (38) | | G/G | 1 (1.2) | 1 (1.5) | 1 (2) | | Bcl-1 Fg | | | | 0.999 | | B1/B1 | 62 (76.5) | 53 (78) | 39 (78) | | B1/B2 | 19 (23.5) | 15 (22) | 11 (22) | | B2/B2 | 0 (0) | 0 (0) | 0 (0) | | -148 Fg | | | | 0.006 | | C/C | 48 (59.3) | 27 (39.7) | 16 (32) | | C/T | 31 (38.3) | 34 (50) | 24 (48) | | T/T | 2 (2.4) | 7 (10.3) | 10 (20) | | Alleles | | | | | | -455 | | | | | | G | 146 (0.9012) | 106 (0.7794) | 80 (0.8000) | 0.0100 | | A | 16 (0.0988) | 30 (0.2206) | 20 (0.2000) | | +1689 | | | | | | T | 135 (0.8333) | 111 (0.8162) | 79 (0.7900) | 0.4350 | | G | 27 (0.1667) | 19 (0.1838) | 21 (0.2100) | | Bcl-1 | | | | | | B1 | 143 (0.8827) | 121 (0.8897) | 89 (0.8900) | 0.9760 | | B2 | 19 (0.1173) | 15 (0.1103) | 11 (0.1100) | | -148 | | | | | | C | 127 (0.7840) | 88 (0.6471) | 56 (0.5600) | 0.0005 | | T | 35 (0.2160) | 48 (0.3529) | 44 (0.4400) |
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SCD: stable coronary disease; UCD: unstable coronary disease; Fg: fibrinogen. Yates’ value. |
