High Serum Uric Acid Is Associated with Tubular Damage and Kidney Inflammation in Patients with Type 2 Diabetes
Table 3
Multiple regression analysis of serum uric acid as a dependent variable adjusting for some clinical and laboratory variables of the study population ().
value
Model 1
Male (%)
-0.546
0.357
-1.527
0.133
BMI (kg/m2)
0.061
0.017
3.486
0.001
Hypertension (%)
1.806
1.210
1.492
0.142
ACE inhibitors (%)
0.125
0.357
0.349
0.729
Other antihypertensive agents (%)
-1.142
1.176
-0.971
0.336
Total cholesterol (mmol/L)
-0.004
0.203
-0.021
0.984
eGFR (mL/min/1.73 m2)
-0.013
0.007
-1.710
0.093
Urinary ACR (mg/g creat)
0.005
0.002
1.977
0.053
Urinary KIM-1 (pg/mL)
-0.001
0.004
-0.176
0.861
Urinary KIM-1 (ng/g creat)
-0.004
0.001
-3.090
0.003
Model 2
Male (%)
-0.304
0.322
-0.944
0.349
BMI (kg/m2)
0.055
0.017
3.341
0.001
Hypertension (%)
1.863
1.226
1.519
0.134
ACE inhibitors (%)
0.348
0.318
1.095
0.278
Other antihypertensive agents (%)
-1.234
1.201
-1.027
0.308
Total cholesterol (mmol/L)
-0.175
0.197
-0.890
0.377
eGFR (mL/min/1.73 m2)
-0.018
0.006
-2.728
0.008
Urinary ACR (mg/g creat)
0.003
0.002
1.328
0.189
Urinary IL-1 (pg/mL)
-0.025
0.020
-1.254
0.215
Urinary IL-1 (ng/g creat)
0.006
0.013
0.537
0.593
Urinary IL-6 (pg/mL)
-0.021
0.022
-0.991
0.326
Urinary IL-6 (ng/g creat)
0.017
0.011
1.545
0.128
Urinary IL-10 (pg/mL)
0.001
0.006
0.043
0.966
Urinary IL-10 (ng/g creat)
0.002
0.004
0.372
0.711
Urinary TNF-alpha (pg/mL)
0.046
0.017
2.673
0.009
Urinary TNF-alpha (ng/g creat)
-0.024
0.010
-2.464
0.017
Regression coefficients (), standard error of (), and statistic with corresponding value. Analyses were performed considering urinary concentrations of KIM-1 and cytokines as absolute values and normalized by urinary creatinine.
