Gas6/TAM Axis in Sepsis: Time to Consider Its Potential Role as a Therapeutic Target

Table 1

The widespread expression of the TAM receptor.

	Tyro3	Axl	Mer
Brain	(i) Microglial cells [4]; (ii) Astrocytes [4]	(i) Microglial cells [4]; (ii) Astrocytes [4]	(i) Microglial cells [4]; (ii) Astrocytes [4]
Heart			(i) Cardiomyocytes [5]
Breast			(i) Mammary epithelial cells [6]
Lung		(i) Macrophages CD11bl^owCD11c^high [7]	(i) Alveolar macrophages [8]
Liver	(i) Kupffer cells [9]	(i) Kupffer cells [9]; (ii) HSCs (q/a) [9]; (iii) LSECs [9]; (iv) Hepatocytes [9]	(i) Kupffer cells [9]; (ii) HSC (a) [9]; (iii) LSEC [9]
Spleen		(i) DCs CD11c^high [10]	(i) Macrophages F4/80^high, B220^–, CD11c^+ and MHCII^+ red pulp [11]; (ii) Macrophages F4/80^+CD68^+ (tingible body) [11]
Kidney	(i) Podocytes [12]		(i) Podocytes [12]
Testis	(i) Sertoli cells [13]	(i) Sertoli cells [13]	(i) Sertoli cells^low [13]; (ii) Leydig cells [13]
Peritoneum		(i) Macrophages [14]	(i) Macrophages [14]
Blood/BM derived	(i) Platelets [15]; (ii) Monocytes^low; (iii) Monocyte-derived macrophages^low [16]; (iv) NK cells [17]; (v) DC CD11c^+ [18]	(i) Platelets [15]; (ii) Monocytes^high; (iii) Monocyte-derived macrophages^low [16]; (iv) NK cells [17]; (v) DC CD11c^+ [18]	(i) Platelets [15]; (ii) Monocytes^low; (iii) Monocyte-derived macrophages^high [16]; (iv) NK cells [17]; (v) DC CD11c^+ [18]; (vi) DCs CD11b^+ and B220^+ [19]; (vii) NKT cells [20]

Italic shows TAM expression located in human cells; all the others were found in murine cells. BM derived: bone marrow derived; HSCs: hepatic stellate cells; LSECs: liver sinusoidal endothelial cells; DCs: dendritic cells; NK: natural killer; NKT: natural killer T.