Genetic Association between NFKBIA and NFKB1 Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis

Table 1

Characteristics of articles enrolled in the meta-analysis.

FA (year)	NOS	Ethnicity	Genotyping method	SC	Cases			Controls			Cancer type	HWE
rs28362491					ins/ins	ins/del	del/del	ins/ins	ins/del	del/del
Lin (2006)	6	Asian	PCR-PAGE	HB	59	103	50	43	100	58	OC	0.993
Lehnerdt (2008)	7	Caucasian; Germany	PCR-RFLP	HB	132	179	53	118	141	48	HNC	0.586
Zhou (2009)	8	Asian	PCR-PAGE	HB	74	67	22	71	90	42	NC	0.177
Lin (2012)	8	Asian	TaqMan	HB	116	246	100	81	271	168	OC	0.099
Liu (2012)	7	Asian	PCR	PB	269	467	170	280	433	193	NC	0.289
Liu (2015)	7	Asian	TaqMan	HB	316	438	152	336	512	224	NC	0.262
Liu (2015)	7	Asian	TaqMan	HB	236	331	117	274	438	195	NC	0.169
Chen (2018)	8	Asian	MassARRAY	HB	124	197	100	163	230	90	OC	0.577
Gupta (2017)	7	Asian	PCR-RFLP	HB	132	162	18	144	146	22	HNC	0.064
rs2233406					CC	CT	TT	CC	CT	TT
Lin (2012)	8	Asian	TaqMan	HB	351	101	10	438	78	4	OC	0.797
Liu (2012)	7	Asian	PCR	PB	706	185	15	694	201	11	NC	0.402
Liu (2015)	7	Asian	TaqMan	HB	701	188	17	813	244	15	NC	0.492
Chen (2018)	8	Asian	MassARRAY	HB	308	108	9	365	110	8	OC	0.931

FA: first author; SC: source of control; OC: oral cancer; NC: nasopharyngeal carcinoma; HNC: head and neck cancer; HB: hospital-based study; PB: population-based study; HWE: Hardy-Weinberg equilibrium; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; PCR: polymerase chain reaction; PCR-PAGE: polymerase chain reaction-polyacrylamide gel electrophoresis.