Genetic Association between NFKBIA and NFKB1 Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis
Table 3
False-positive report probability values for associations between the rs28362491 polymorphism and the HNC risk.
Variables
OR (95% CI)
a
Powerb
Prior probability
0.25
0.1
0.01
0.001
0.0001
D versus I
PCR-PAGE
0.74 (0.61-0.91)
0.004
0.839
0.015
0.044
0.338
0.837
0.981
TaqMan
0.79 (0.69-0.91)
0.001
0.991
0.003
0.010
0.098
0.523
0.916
NC
0.87 (0.78-0.96)
0.006
1.000
0.016
0.048
0.355
0.847
0.982
DD versus II
Overall
0.76 (0.60-0.97)
0.027
0.854
0.088
0.225
0.761
0.970
0.997
PCR-PAGE
0.57 (0.38-0.85)
0.006
0.221
0.073
0.192
0.723
0.963
0.996
TaqMan
0.61 (0.45-0.83)
0.002
0.286
0.017
0.050
0.364
0.853
0.983
NC
0.75 (0.62-0.90)
0.002
0.897
0.007
0.020
0.180
0.688
0.957
DI versus II
TaqMan
0.83 (0.69-1.00)
0.050
0.989
0.132
0.313
0.833
0.981
0.998
DD+DI versus II
PCR-PAGE
0.67 (0.49-0.92)
0.013
0.512
0.072
0.190
0.720
0.963
0.996
TaqMan
0.75 (0.60-0.94)
0.013
0.847
0.042
0.117
0.594
0.937
0.993
DD versus DI+II
Overall
0.80 (0.68-0.95)
0.011
0.981
0.032
0.091
0.524
0.918
0.991
PCR-PAGE
0.69 (0.49-0.98)
0.038
0.576
0.166
0.374
0.868
0.985
0.998
TaqMan
0.70 (0.60-0.83)
0.00004
0.713
<0.001
0.001
0.006
0.054
0.363
NC
0.78 (0.68-0.89)
0.0002
0.990
0.001
0.002
0.022
0.184
0.693
aChi-square test was adopted to calculate the genotype frequency distributions. bStatistical power was calculated using the number of observations in the subgroup and the OR and values in this table.
