De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study
Table 2
Multivariate Cox proportional hazards analyses of AST/ALT ratio on overall survival, cancer-specific survival, and recurrence-free survival.
Variables
Overall survival
Cancer-specific survival
Recurrence-free survival
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Age
1.03 (1.00-1.01)
0.032
1.05 (1.01-1.09)
0.022
1.01 (0.97-1.04)
0.633
BMI
0.92 (0.84-1.01)
0.099
0.92 (0.84-1.02)
0.103
1.06 (1.00-1.13)
0.043
Tumor size
1.16 (1.09-1.24)
<0.001
1.16 (1.09-1.24)
<0.001
1.13 (1.07-1.20)
<0.001
High tumor grade
1.58 (1.10-2.28)
0.013
1.65 (1.09-2.49)
0.017
1.30 (0.90-1.88)
0.159
≥pT2 stage
3.30 (1.18-9.21)
0.022
5.78 (2.51-13.35)
<0.001
5.14 (2.05-12.90)
<0.001
≥N1 stage
1.37 (1.06-1.77)
0.014
1.35 (1.05-1.74)
0.018
1.54 (1.20-1.97)
<0.001
≥M1 stage
1.68 (0.23-11.99)
0.605
3.89 (0.45-33.90)
0.219
1.73 (0.22-13.58)
0.604
NACH
1.21 (0.60-2.42)
0.594
1.33 (0.63-2.78)
0.191
1.86 (0.80-4.26)
0.142
AST/ALT ratio
AST/ALT ≤1.1
Reference
Reference
Reference
AST/ALT >1.1
2.15 (1.23-3.73)
0.007
2.05 (1.65-2.56)
<0.001
1.32 (0.69-2.56)
0.087
BMI: body mass index; NACH: neoadjuvant chemotherapy; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
