De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched Study
Table 3
Multivariate Cox proportional hazards analyses of AST/ALT ratio on overall survival, cancer-specific survival, and recurrence-free survival after propensity score matching.
Variables
Overall survival
Cancer-specific survival
Recurrence-free survival
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Age
1.03 (1.01-1.04)
<0.001
1.02 (0.99-1.03)
0.092
1.00 (0.99-1.02)
0.876
BMI
0.92 (0.87-0.96)
<0.001
0.94 (0.88-0.99)
0.034
0.97 (0.92-1.02)
0.299
Tumor size
1.09 (1.05-1.15)
<0.001
1.11 (1.05-1.17)
<0.001
1.09 (1.04-1.14)
0.001
High tumor grade
1.51 (1.04-2.18)
0.018
1.70 (1.13-2.55)
0.010
1.37 (0.95-1.98)
0.093
≥pT2 stage
5.36 (2.12-13.51)
<0.001
6.99 (3.00-16.28)
<0.001
13.47 (4.25-42.65)
<0.001
≥N1 stage
1.36 (1.05-1.75)
0.018
1.35 (1.05-1.74)
0.018
1.60 (1.25-2.06)
0.002
≥M1 stage
1.27 (0.74-2.18)
0.394
1.71 (0.98-3.00)
0.060
2.10 (1.23-3.60)
0.007
NACH
0.51 (0.35-0.75)
0.001
0.45 (0.29-0.69)
<0.001
0.47 (0.32-0.67)
<0.001
AST/ALT ratio
AST/ALT ≤1.1
Reference
Reference
Reference
Reference
Reference
Reference
AST/ALT >1.1
1.57 (1.20-2.06)
0.001
1.76 (1.26-2.48)
0.001
1.53 (1.15-2.05)
0.004
BMI: body mass index; NACH: neoadjuvant chemotherapy; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
