Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis

Table 2

The pooled associations between different situations of SCC-Ag expression and the prognosis of patients with cervical cancer.

Outcome subgroup	No. of patients	No. of studies	HR (95% CI)	value	Heterogeneity
					OS	2441	11	2.22 (1.38-3.57)^b	0.002	91.4	<0.001
HR obtain method
Reported in the text	1918	7	1.72 (1.04-2.85)^b	0.038	91.4	<0.001
Data extrapolated	523	4	3.92 (1.40-10.95)^b	0.009	78.8	0.003
Analysis type
Multivariate	1918	7	1.72 (1.04-2.85)^b	0.038	91.4	<0.001
Univariate	523	4	3.92 (1.40-10.95)^b	0.009	78.8	0.003
Ethnicity
Asian	1950	8	1.99 (1.18-3.36)^b	0.009	96.7	<0.001
Caucasian	491	3	2.78 (1.29-5.99)^b	0.010	81.9	0.004
DFS	1462	9	2.17 (1.84-2.57)^a	<0.001	23.3	0.236
HR obtain method
Reported in the text	815	5	2.23 (1.83-2.72)^a	<0.001	28.5	0.231
Data extrapolated	647	4	2.05 (1.50-2.80)^a	<0.001	35.3	0.201
Analysis type
Multivariate	815	5	2.23 (1.83-2.72)^a	<0.001	28.5	0.231
Univariate	647	4	2.05 (1.50-2.80)^a	<0.001	35.3	0.201
Ethnicity
Asian	1348	7	1.95 (1.57-2.42)^a	<0.001	21.9	0.262
Caucasian	294	2	2.57 (1.97-3.36)^a	<0.001	0	0.652
PFS	1321	5	2.70 (1.11-6.53)^b	0.028	94.8	<0.001

OS: overall survival; DFS: disease-free survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval. ^aFixed effects model. ^bRandom effects model.