Research Article
Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis
Table 2
The pooled associations between different situations of SCC-Ag expression and the prognosis of patients with cervical cancer.
| Outcome subgroup | No. of patients | No. of studies | HR (95% CI) | value | Heterogeneity | | |
| OS | 2441 | 11 | 2.22 (1.38-3.57)b | 0.002 | 91.4 | <0.001 | HR obtain method | | | | | | | Reported in the text | 1918 | 7 | 1.72 (1.04-2.85)b | 0.038 | 91.4 | <0.001 | Data extrapolated | 523 | 4 | 3.92 (1.40-10.95)b | 0.009 | 78.8 | 0.003 | Analysis type | | | | | | | Multivariate | 1918 | 7 | 1.72 (1.04-2.85)b | 0.038 | 91.4 | <0.001 | Univariate | 523 | 4 | 3.92 (1.40-10.95)b | 0.009 | 78.8 | 0.003 | Ethnicity | | | | | | | Asian | 1950 | 8 | 1.99 (1.18-3.36)b | 0.009 | 96.7 | <0.001 | Caucasian | 491 | 3 | 2.78 (1.29-5.99)b | 0.010 | 81.9 | 0.004 | DFS | 1462 | 9 | 2.17 (1.84-2.57)a | <0.001 | 23.3 | 0.236 | HR obtain method | | | | | | | Reported in the text | 815 | 5 | 2.23 (1.83-2.72)a | <0.001 | 28.5 | 0.231 | Data extrapolated | 647 | 4 | 2.05 (1.50-2.80)a | <0.001 | 35.3 | 0.201 | Analysis type | | | | | | | Multivariate | 815 | 5 | 2.23 (1.83-2.72)a | <0.001 | 28.5 | 0.231 | Univariate | 647 | 4 | 2.05 (1.50-2.80)a | <0.001 | 35.3 | 0.201 | Ethnicity | | | | | | | Asian | 1348 | 7 | 1.95 (1.57-2.42)a | <0.001 | 21.9 | 0.262 | Caucasian | 294 | 2 | 2.57 (1.97-3.36)a | <0.001 | 0 | 0.652 | PFS | 1321 | 5 | 2.70 (1.11-6.53)b | 0.028 | 94.8 | <0.001 |
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OS: overall survival; DFS: disease-free survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval. aFixed effects model. bRandom effects model.
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