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Research Article

Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure

Table 4

(a) Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in HF patients due to CAD and controls

Controls ( (%))Patients ( (%))OR (95% CI)a

GSTA1
A/A112 (41)38 (35)1.0b
A/B+B/B162 (59)70 (65)1.8 (0.9-3.5)0.075
GSTM1
 Active137 (50)53 (49)1.0b
 Null137 (50)56 (51)1.1 (0.6-2.0)0.749
GSTT1
 Active203 (74)82 (75)1.0b
 Null71 (26)27 (25)1.0 (0.5-2.0)0.935
GSTP1Ile105Val (rs1695)
Ile/Ile115 (42)39 (37)1.0b
Ile/Val+Val/Val159 (58)68 (63)1.9 (1.0-3.6)0.056
GSTP1Ala114Val (rs1138272)
Ala/Ala205 (85)90 (86)1.0b
Ala/Val+Val/Val38 (15)15 (14)0.5 (0.2-1.3)0.157
Combined GSTA1/GSTP1 (rs1695)
AA/IleIle54 (20)16 (15)1.0b
AA/IleVal+ValVal58 (21)22 (21)1.4 (0.5-4.1)0.539
AB+BB/IleIle61 (22)23 (22)1.4 (0.5-4.0)0.560
AB+BB/IleVal+ValVal101 (37)45 (42)2.8 (1.1-7.3)0.033
Combined GSTA1/GSTP1 (rs1138272)
AA/AlaAla28 (11)9 (9)1.0b
AA/AlaVal+ValVal84 (33)29 (28)1.6 (0.4-5.4)0.490
AB+BB/AlaAla24 (9)7 (7)0.9 (0.2-3.4)0.906
AB+BB/AlaVal+ValVal121 (47)60 (57)2.1 (1.0-4.5)0.056

CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios adjusted for gender, age, smoking, hypertension, and diabetes. bReference group. Statistically significant in comparison with the reference genotype ().
(b) Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in IDC patients and controls

GenotypeControls ( (%))Patients ( (%))OR (95% CI)a

GSTA1
A/A112 (41)30 (35)1.0b
A/B+B/B162 (59)55 (65)1.2 (0.6-2.2)0.660
GSTP1Ile105Val (rs1695)
Ile/Ile115 (42)29 (34)1.0b
Ile/Val+Val/Val159 (58)56 (66)1.4 (0.7-2.7)0.284
GSTM1
 Active137 (50)39 (46)1.0b
 Null137 (50)46 (54)1.2 (0.6-2.2)0.620
GSTT1
 Active203 (74)64 (75)1.0b
 Null71 (26)21 (25)0.9 (0.4-1.9)0.854
Combined GSTA1/GSTP1
AA/IleIle54 (20)13 (15)1.0b
AA/IleVal+ValVal58 (21)17 (20)1.3 (0.5-3.6)0.618
AB+BB/IleIle61 (22)16 (19)1.0 (0.4-2.9)0.924
AB+BB/IleVal+ValVal101 (37)39 (46)1.5 (0.6-3.8)0.348

CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios adjusted for gender, age, smoking, hypertension, and diabetes. bReference group.

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