Research Article
Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure
(a) Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in HF patients due to CAD and controls |
| | Controls ( (%)) | Patients ( (%)) | OR (95% CI)a | |
| | GSTA1 | | A/A | 112 (41) | 38 (35) | 1.0b | | | A/B+B/B | 162 (59) | 70 (65) | 1.8 (0.9-3.5) | 0.075 | | GSTM1 | | Active | 137 (50) | 53 (49) | 1.0b | | | Null | 137 (50) | 56 (51) | 1.1 (0.6-2.0) | 0.749 | | GSTT1 | | | | | | Active | 203 (74) | 82 (75) | 1.0b | | | Null | 71 (26) | 27 (25) | 1.0 (0.5-2.0) | 0.935 | | GSTP1Ile105Val (rs1695) | | | | | | Ile/Ile | 115 (42) | 39 (37) | 1.0b | | | Ile/Val+Val/Val | 159 (58) | 68 (63) | 1.9 (1.0-3.6) | 0.056 | | GSTP1Ala114Val (rs1138272) | | | | | | Ala/Ala | 205 (85) | 90 (86) | 1.0b | | | Ala/Val+Val/Val | 38 (15) | 15 (14) | 0.5 (0.2-1.3) | 0.157 | | Combined GSTA1/GSTP1 (rs1695) | | | | | | AA/IleIle | 54 (20) | 16 (15) | 1.0b | | | AA/IleVal+ValVal | 58 (21) | 22 (21) | 1.4 (0.5-4.1) | 0.539 | | AB+BB/IleIle | 61 (22) | 23 (22) | 1.4 (0.5-4.0) | 0.560 | | AB+BB/IleVal+ValVal | 101 (37) | 45 (42) | 2.8 (1.1-7.3) | 0.033 | | Combined GSTA1/GSTP1 (rs1138272) | | | | | | AA/AlaAla | 28 (11) | 9 (9) | 1.0b | | | AA/AlaVal+ValVal | 84 (33) | 29 (28) | 1.6 (0.4-5.4) | 0.490 | | AB+BB/AlaAla | 24 (9) | 7 (7) | 0.9 (0.2-3.4) | 0.906 | | AB+BB/AlaVal+ValVal | 121 (47) | 60 (57) | 2.1 (1.0-4.5) | 0.056 |
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CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios adjusted for gender, age, smoking, hypertension, and diabetes. bReference group. Statistically significant in comparison with the reference genotype ( ). |
(b) Distribution of GSTA1, GSTP1, GSTM1, and GSTT1 genotypes in IDC patients and controls |
| | Genotype | Controls ( (%)) | Patients ( (%)) | OR (95% CI)a | |
| | GSTA1 | | A/A | 112 (41) | 30 (35) | 1.0b | | | A/B+B/B | 162 (59) | 55 (65) | 1.2 (0.6-2.2) | 0.660 | | GSTP1Ile105Val (rs1695) | | Ile/Ile | 115 (42) | 29 (34) | 1.0b | | | Ile/Val+Val/Val | 159 (58) | 56 (66) | 1.4 (0.7-2.7) | 0.284 | | GSTM1 | | | | | | Active | 137 (50) | 39 (46) | 1.0b | | | Null | 137 (50) | 46 (54) | 1.2 (0.6-2.2) | 0.620 | | GSTT1 | | | | | | Active | 203 (74) | 64 (75) | 1.0b | | | Null | 71 (26) | 21 (25) | 0.9 (0.4-1.9) | 0.854 | | Combined GSTA1/GSTP1 | | | | | | AA/IleIle | 54 (20) | 13 (15) | 1.0b | | | AA/IleVal+ValVal | 58 (21) | 17 (20) | 1.3 (0.5-3.6) | 0.618 | | AB+BB/IleIle | 61 (22) | 16 (19) | 1.0 (0.4-2.9) | 0.924 | | AB+BB/IleVal+ValVal | 101 (37) | 39 (46) | 1.5 (0.6-3.8) | 0.348 |
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CI: confidence interval; OR: odds ratio. aLogistic regression to compute odds ratios adjusted for gender, age, smoking, hypertension, and diabetes. bReference group.
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