Identification of Key Pathways and Genes in the Orai2 Mediated Classical and Mesenchymal Subtype of Glioblastoma by Bioinformatic Analyses

Figure 1

Orai2 expression was increased in GBM, and elevated Orai2 expression was a prognostic indicator of poor survival in glioma patients. (a) ORAI2 expression in various tumors from GEPIA (Gene Expression Profiling Interactive Analysis). (b, c) Orai2 level was increased in GBM compared with normal brain samples from the French, Sun, and TCGA datasets. NB: normal brain samples. (d, e) Compared with lower-grade glioma (WHO II and WHO III) and other glioma tissue types, Orai2 expression levels were higher in GBM (WHO IV). (f) The levels of Orai2 were analyzed in GBM tissues from the TCGA dataset; Orai2 was significantly upregulated in the classical and mesenchymal subtypes of GBM. (g, h) Kaplan-Meier survival curve analysis indicated that patients with higher Orai2 expression in the classical and mesenchymal subtypes had a shorter overall survival, while the other two subtypes had no prognostic value.

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