The Role of Circulating CD16+CD56+ Natural Killer Cells in the Screening, Diagnosis, and Staging of Colorectal Cancer before Initial Treatment

Table 2

The cutoff value of CD16+CD56+ NK cells in prediction of different CRC stages.

Groups	AUC	Threshold (% in lymphocytes)	Case numbers	OR (95% CI)	value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Healthy vs. cancer	0.725	19.7	48/60: 61/264	0.08 (0.04, 0.15)	<0.001	80.0	76.9	44.0	94.4
Healthy+stages 1&2 vs. stages 3&4	0.892	15.6	157/186: 38/138	0.07 (0.04, 0.12)	<0.001	84.4	72.5	80.5	77.5
Stages 1&2 vs. stages 3&4	0.878	15.6	109/126: 38/138	0.06 (0.03, 0.11)	<0.001	86.5	72.5	74.2	85.5

AUC: area under the curve. Case number above the threshold/total case number in corresponding groups.