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Disease Markers
Volume 2019, Article ID 7378967, 9 pages
https://doi.org/10.1155/2019/7378967
Research Article

MicroRNA-224 Promotes Tumorigenesis through Downregulation of Caspase-9 in Triple-Negative Breast Cancer

1Department of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin, China
2Department of Hepatopancreatobiliary Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China

Correspondence should be addressed to Miao He; moc.kooltuo@6101yhoaiM and Shixing Qiao; moc.kooltuo@88102oaiqgnixihs

Received 22 June 2018; Revised 5 November 2018; Accepted 26 November 2018; Published 11 February 2019

Academic Editor: Mirte Mayke Streppel

Copyright © 2019 Li Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. D. Foulkes, I. E. Smith, and J. S. Reis-Filho, “Triple-negative breast cancer,” The New England Journal of Medicine, vol. 363, no. 20, pp. 1938–1948, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. L. G. Fulford, J. S. Reis-Filho, K. Ryder et al., “Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival,” Breast Cancer Research, vol. 9, no. 1, p. R4, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. A. Thike, P. Y. Cheok, A. R. Jara-Lazaro, B. Tan, P. Tan, and P. H. Tan, “Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer,” Modern Pathology, vol. 23, no. 1, pp. 123–133, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Mathe, R. J. Scott, and K. A. Avery-Kiejda, “miRNAs and other epigenetic changes as biomarkers in triple negative breast cancer,” International Journal of Molecular Sciences, vol. 16, no. 12, pp. 28347–28376, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. C. M. Croce, “Causes and consequences of microRNA dysregulation in cancer,” Nature Reviews Genetics, vol. 10, no. 10, pp. 704–714, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Lujambio and S. W. Lowe, “The microcosmos of cancer,” Nature, vol. 482, no. 7385, pp. 347–355, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. G. A. Calin and C. M. Croce, “MicroRNA signatures in human cancers,” Nature Reviews Cancer, vol. 6, no. 11, pp. 857–866, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Radojicic, A. Zaravinos, T. Vrekoussis, M. Kafousi, D. A. Spandidos, and E. N. Stathopoulos, “MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer,” Cell Cycle, vol. 10, no. 3, pp. 507–517, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Cascione, P. Gasparini, F. Lovat et al., “Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer,” PLoS One, vol. 8, no. 2, article e55910, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. E. N. Howe, D. R. Cochrane, and J. K. Richer, “Targets of miR-200c mediate suppression of cell motility and anoikis resistance,” Breast Cancer Research, vol. 13, no. 2, p. R45, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Kleivi Sahlberg, G. Bottai, B. Naume et al., “A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients,” Clinical Cancer Research, vol. 21, no. 5, pp. 1207–1214, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Zhu, M. Sachdeva, F. Wu, Z. Lu, and Y.-Y. Mo, “Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner,” Oncogene, vol. 29, no. 12, pp. 1763–1772, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Huang, T. Dai, X. Lin et al., “MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells,” Biochemical and Biophysical Research Communications, vol. 425, no. 2, pp. 127–133, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. A. B. Hui, W. Shi, P. C. Boutros et al., “Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues,” Laboratory Investigation, vol. 89, no. 5, pp. 597–606, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Wang, A. T. C. Lee, J. Z. I. Ma et al., “Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target,” Journal of Biological Chemistry, vol. 283, no. 19, pp. 13205–13215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. N. Shen, L. F. Wang, Y. F. Jia, Y. Q. Hao, L. Zhang, and H. Wang, “Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer,” Diagnostic Pathology, vol. 8, no. 1, p. 69, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Lu, S. Wang, S. Geng, S. Ma, Z. Liang, and B. Jiao, “Upregulation of microRNA-224 confers a poor prognosis in glioma patients,” Clinical & Translational Oncology, vol. 15, no. 7, pp. 569–574, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Cui, W. Meng, H. L. Sun et al., “MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 31, pp. E4288–E4297, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. W. T. Liao, T. T. Li, Z. G. Wang et al., “MicroRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2,” Clinical Cancer Research, vol. 19, no. 17, pp. 4662–4672, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Mavridis, K. Stravodimos, and A. Scorilas, “Downregulation and prognostic performance of microRNA 224 expression in prostate cancer,” Clinical Chemistry, vol. 59, no. 1, pp. 261–269, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. F. An, A. V. Olaru, E. Mezey et al., “MicroRNA-224 induces G1/S checkpoint release in liver cancer,” Journal of Clinical Medicine, vol. 4, no. 9, pp. 1713–1728, 2015. View at Publisher · View at Google Scholar
  23. C. Scisciani, S. Vossio, F. Guerrieri et al., “Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways,” Journal of Hepatology, vol. 56, no. 4, pp. 855–861, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. H. W. Hwang, L. L. Baxter, S. K. Loftus et al., “Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A,” Pigment Cell & Melanoma Research, vol. 27, no. 5, pp. 777–787, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Wang, J. Ren, Y. Gao et al., “MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival,” PLoS One, vol. 8, no. 7, article e68744, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Zhao, T. Bi, Z. Qu, J. Jiang, S. Cui, and Y. Wang, “Expression of miR-224-5p is associated with the original cisplatin resistance of ovarian papillary serous carcinoma,” Oncology Reports, vol. 32, no. 3, pp. 1003–1012, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Upraity, S. Kazi, V. Padul, and N. V. Shirsat, “miR-224 expression increases radiation sensitivity of glioblastoma cells,” Biochemical and Biophysical Research Communications, vol. 448, no. 2, pp. 225–230, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. L. A. Allan and P. R. Clarke, “Apoptosis and autophagy: regulation of caspase-9 by phosphorylation,” The FEBS Journal, vol. 276, no. 21, pp. 6063–6073, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Shi, “Caspase activation: revisiting the induced proximity model,” Cell, vol. 117, no. 7, pp. 855–858, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Li, D. Nijhawan, I. Budihardjo et al., “Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade,” Cell, vol. 91, no. 4, pp. 479–489, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Chao, E. N. Shiozaki, S. M. Srinivasula, D. J. Rigotti, R. Fairman, and Y. Shi, “Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation,” PLoS Biology, vol. 3, no. 6, article e183, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Laperchia, C. Tesoriero, P. F. Seke-Etet et al., “Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis,” PLoS Neglected Tropical Diseases, vol. 11, no. 8, article e0005854, 2017. View at Publisher · View at Google Scholar · View at Scopus
  33. M. C. Martin, L. A. Allan, E. J. Mancini, and P. R. Clarke, “The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125,” The Journal of Biological Chemistry, vol. 283, no. 7, pp. 3854–3865, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. H. Cardone, N. Roy, H. R. Stennicke et al., “Regulation of cell death protease caspase-9 by phosphorylation,” Science, vol. 282, no. 5392, pp. 1318–1321, 1998. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Marusawa, S. Matsuzawa, K. Welsh et al., “HBXIP functions as a cofactor of survivin in apoptosis suppression,” The EMBO Journal, vol. 22, no. 11, pp. 2729–2740, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. D. H. Floyd, Y. Zhang, B. K. Dey et al., “Novel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim,” PLoS One, vol. 9, no. 5, article e96239, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Shang, F. Yang, Y. Wang et al., “MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells,” Journal of Cellular Biochemistry, vol. 115, no. 4, pp. 772–784, 2014. View at Publisher · View at Google Scholar · View at Scopus