Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Table 3

Meta-analysis of the association between LMR and clinicopathological features of bladder cancer.

Characteristics	No. of studies	No. of patients	OR (95% CI)		Heterogeneity
					(%)
Age (≥60 vs. <60)	3	626	2.07 (1.22-3.50)	0.007	42	0.18
Gender (male vs. female)	4	4,818	1.18 (0.68-2.04)	0.56	70	0.02
Smoking status (always/current vs. never)	2	394	0.95 (0.63-1.45)	0.82	0	0.80
Differentiation (low vs. moderate/high)	5	4,886	1.60 (1.10-2.32)	0.01	35	0.19
Tumor size (>3 cm vs. <3 cm)	2	496	1.86 (0.74-4.71)	0.19	71	0.06
T stage (III-IV vs. I-II)	3	4,390	1.13 (1.01-1.28)	0.04	0	0.79
Lymph node metastasis (yes vs. no)	3	4,390	1.22 (1.06-1.39)	0.005	0	0.67
Distant metastasis (yes vs. no)	1	124	1.46 (0.37-5.73)	0.59	—	—
Multiplicity (multiple vs. solitary)	2	496	1.04 (0.68-1.58)	0.86	0	0.49
Concomitant Cis (yes vs. no)	2	4,322	0.88 (0.78-0.99)	0.03	0	0.87

Cis: carcinoma in situ.