Preoperative Anemia or Low Hemoglobin Predicts Poor Prognosis in Gastric Cancer Patients: A Meta-Analysis

Table 2

The results of subgroup analyses for the prognostic value of preoperative anemia.

	HR	95% CI		(%)	Publication bias
Overall survival
Overall	1.33	1.21-1.45	<0.01	48.90%	;
Sample size
≥500	1.27	1.16-1.39	<0.01	42.40%	;
<500	1.48	1.18-1.86	<0.01	50.80%	;
Cut-off point
≥110	1.32	1.21-1.44	<0.01	28.40%	;
<110	1.48	1.21-1.80	<0.01	31.30%	;
Study quality
≥7	1.40	1.20-1.63	<0.01	49.30%	;
<7	1.28	1.13-1.44	<0.01	46.80%	;
Study analysis type
Multivariate type	1.25	1.13-1.39	<0.01	45.90%	;
Univariate type	1.65	1.39-1.95	<0.01	71.60%	;
Tumor stage
I–II	1.33	1.04-1.71	0.03	20.00%	;
III	1.24	0.68-2.26	0.49	77.10%	;
Country
Asia	1.31	1.18-1.45	<0.01	53.90%	;
Non-Asia	1.44	1.17-1.78	<0.01	0.00%	;
Disease-free survival
Overall	1.62	1.13-2.32	<0.01	91.10%	;
Sample size
≥500	1.55	1.03-2.31	0.03	83.10%	;
<500	1.76	0.94-3.26	0.07	90.60%	;
Cut-off point
≥110	1.62	1.06-2.49	0.03	84.90%	;
Study analysis type
Multivariable type	1.09	0.91-1.30	0.35	51.60%	;
Univariable type	2.07	1.21-3.54	<0.01	84.60%	;
Country
Asia	1.62	1.13-2.32	<0.01	91.10%	;

Abbreviations: CI: confidence interval; HR: hazard ratio; : degree of heterogeneity; : for the HR; “/”: not applicable due to limited number of studies.