Research Article
CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study
Table 3
Association analysis of SNPs (rs2283291 and rs4648635) with SCZ as stratified by gender (n (%)).
| | Genotype/allele | Total | Male | Female | | SCZ () | HC () | | | SCZ () | HC () | | | SCZ () | HC () | | |
| | rs2283291 | | | | | | | | | | | | | | GG | 200 (44.9) | 246 (47.8) | 5.054 | 0.080 | 117 (42.2) | 105 (49.1) | 8.151 | 0.017 | 83 (49.4) | 141 (46.8) | 0.592 | 0.744 | | GA | 211 (47.4) | 213 (41.4) | | | 139 (50.2) | 82 (38.3) | | | 72 (42.9) | 131 (43.5) | | | | AA | 34 (7.6) | 56 (10.9) | | | 21 (7.6) | 27 (12.6) | | | 13 (7.7) | 29 (9.6) | | | | G | 611 (68.7) | 705 (68.4) | 0.009 | 0.923 | 373 (67.3) | 292 (68.2) | 0.089 | 0.766 | 238 (70.8) | 413 (68.6) | 0.504 | 0.478 | | A | 279 (31.3) | 325 (31.6) | | | 181 (32.7) | 136 (31.8) | | | 98 (29.2) | 189 (31.4) | | | | rs4648635 | | | | | | | | | | | | | | CC | 361 (81.1) | 414 (80.4) | 0.173 | 0.917 | 224 (80.9) | 169 (79.0) | — | 0.164 | 137 (81.5) | 245 (81.4) | — | 0.697 | | CT | 79 (17.8) | 96 (18.6) | | | 49 (17.7) | 45 (21.0) | | | 30 (17.9) | 51 (16.9) | | | | TT | 5 (1.1) | 5 (1.0) | | | 4 (1.4) | 0 (0.0) | | | 1 (0.6) | 5 (1.7) | | | | C | 801 (90.0) | 924 (89.7) | 0.044 | 0.833 | 497 (89.7) | 383 (89.5) | 0.013 | 0.909 | 304 (90.5) | 541 (89.9) | 0.090 | 0.765 | | T | 89 (10.0) | 106 (10.3) | | | 57 (10.3) | 45 (10.5) | | | 32 (9.5) | 61 (10.1) | | |
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SCZ: schizophrenic; HC: healthy control. Fisher’s exact test. |
