Expression and Clinical Relevance of SOX9 in Gastric Cancer

Table 2

Disease-free survival univariable and multivariable Cox regression analysis in gastric cancer.

	Number of events	Univariable analysis			Multivariable analysis
		HR	95% CI	value	HR	95% CI	value
Laurén classification
Intestinal	28	1			1
Diffuse	7	1.17	0.51-2.68	0.71	0.71	0.31-1.66	0.44
Mixed	23	1.78	1.03-3.10	0.04	1.08	0.58-1.99	0.81
Growth pattern
Infiltrative	62	1			1
Expansive	10	0.45	0.23-0.88	0.02	0.52	0.20-1.37	0.19
TNM
I	5	1			1
II	26	8.10	3.11-21.12	<0.01	9.19	2.64-32.01	<0.01
III	42	24.91	9.81-63.30	<0.01	23.40	6.74-81-23	<0.01
Resection margins
R0	67	1			1
R1/R2	5	14.33	5.38-38.19	<0.01	7.83	2.54-25.02	<0.01
Vascular invasion
No	24	1			1
Yes	49	2.28	1.40-3.72	<0.01	0.90	0.49-1.65	0.73
Perineural invasion
No	26	1			1
Yes	47	3.10	1.92-5.02	<0.01	0.64	0.35-1.17	0.15
SOX9
No	21	1			1
Yes	52	0.58	0.35-0.97	0.04	0.90	0.50-1.62	0.72

Notes. values (statistical significance ) were obtained using univariable and multivariable Cox proportional hazards regression analysis (Wald). Comparisons with . HR = hazard ratio; CI = confidence interval.