High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients
Table 2
Univariate and multivariate analysis of prognostic factors for overall survival in gastric cancer patients.
Univariate analysis
Multivariate analysis
HR
95% CI
HR
95% CI
Gender
Male vs. female
1.014
0.903
(0.816, 1.258)
Age
≤60 vs. >60
1.167
0.116
(0.963, 1.413)
Histological type
Tubular vs. mucinous vs. mixed (tubular and mucinous) vs. signet ring cells vs. othersa
1.018
0.698
(0.930, 1.114)
Differentiation
Well vs. middle vs. poor
1.526
<0.001
(1.273, 1.829)
1.096
0.366
(0.898, 1.339)
T
Tis vs. T1+T2 vs. T3+T4
2.723
<0.001
(2.207, 3.360)
1.317
0.083
(0.964, 1.798)
N
N0 vs. N1 vs. N2 vs. N3
1.700
<0.001
(1.568, 1.844)
1.265
0.002
(1.093, 1.463)
M
M0 vs. M1
3.503
<0.001
(2.556, 4.800)
2.176
<0.001
(1.534, 3.088)
TNM stage
0+I vs. II vs. III+IV
2.686
<0.001
(2.331, 3.096)
1.453
0.022
(1.054, 2.004)
SALM3 expression in tumor cells
High vs. low or none
1.785
<0.001
(1.473, 2.165)
1.471
<0.001
(1.210, 1.789)
SALM3 expression in stroma
High vs. low or none
2.262
<0.001
(1.868, 2.740)
1.525
<0.001
(1.247, 1.865)
Combination of tumor cells and fibroblasts
I vs. IV
2.137
0.023
(1.124, 2.537)
1.621
0.036
(1.312, 2.472)
II vs. IV
1.276
0.616
(0.714, 2.328)
III vs. IV
1.769
0.548
(1.357, 2.664)
;aOthers: papillary adenocarcinoma, 5 cases; adenosquamous carcinoma, 6 cases; squamous cell carcinoma, 7 cases; undifferentiated carcinoma, 1 case; small cell malignant tumor, 9 cases; carcinoid, 2 cases; focal cancer, 2 cases. Four groups were classified according to the SALM3 expression in tumor cells and/or stroma: group I has low expression of both, group II has high expression of tumor cells and low expression of stroma, group III has low expression of tumor cells and high expression of stroma, and group IV has high expression of both.
