Genetic Polymorphisms of IFNG and IFNGR1 with Latent Tuberculosis Infection

Table 4

Haplotypes of the IFNG and IFNGR1 genes and their distributions in the three groups.

Gene/haplotype	LTBI vs. PTB				HCS vs. LTBI
	Case (%)	Control (%)		OR (95%CI)	Case (%)	Control (%)		OR (95%CI)
IFNG
CA	141.99 (0.34)	105.98 (0.31)	0.354	1.20 (0.85-1.57)	105.98 (0.31)	131.98 (0.36)	0.138	0.79 (0.58-1.08)
CG	0.01 (0.00)	0.02 (0.00)	—	—	0.02 (0.00)	0.02 (0.00)	—	—
TA	219.01 (0.52)	183.02 (0.53)	0.824	0.97 (0.73-1.29)	183.02 (0.53)	186.02 (0.51)	0.526	1.10 (0.82-1.48)
TG	56.99 (0.14)	54.98 (0.16)	0.362	0.83 (0.56-1.24)	54.98 (0.16)	47.98 (0.13)	0.528	1.26 (0.83-1.92)
IFNGR1
AGTC	53.00 (0.13)	33.00 (0.10)	0.197	1.35 (0.85-2.15)	33 (0.10)	46 (0.13)	0.234	0.75 (0.47-1.21)
GATC	165.00 (0.40)	146.00 (0.42)	0.341	0.87 (0.65-1.16)	146 (0.42)	129.00 (0.35)	0.033	1.39 (1.03-1.89)
GGCT	101.63 (0.24)	92.00 (0.27)	0.394	0.87 (0.63-1.20)	92.00 (0.27)	107.00 (0.29)	0.538	0.90 (0.65-1.25)
GGTC	2.63 (0.01)	6.00 (0.02)	—	—	6.00 (0.02)	1 (0.01)	—	—
GGTT	95.37 (0.23)	67.00 (0.20)	0.295	1.21 (0.85-1.72)	67 (0.20)	83 (0.23)	0.345	0.84 (0.59-1.21)

CI: confidence interval; OR: odds ratio; PTB: pulmonary tuberculosis; LTBI: latent tuberculosis infection; HCS: healthy control subjects.