Disease Markers / 2019 / Article / Fig 3

Research Article

MicroRNA Signatures in Malignant Pleural Mesothelioma Effusions

Figure 3

Fibulin-3 mRNA is expressed significantly higher in MPM PE cells. (a) Mesothelin and (b) fibulin-3 mRNA were measured in cells isolated from PE using qRT-PCR. Expression was plotted on a logarithmic scale, and PGK-1 was used as an endogenous control. The line within the boxes represents the median values, and the top and bottom of the boxes indicate the interquartile ranges. The whiskers demonstrate the upper and lower adjacent values for each disease group (). (c) The efficiency of using fibulin-3 to differentiate MPM from other PE-causing diseases was assessed using ROC curve analysis and expressed as the AUC. The ROC curve for miR-200c, miR-210, and miR-143 in the same samples is included for comparison.

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