Amino Acid-Based Metabolic Profile Provides Functional Assessment and Prognostic Value for Heart Failure Outpatients

<div>HOP scores in different functional classes as defined by cardiopulmonary exercise test (CPET). (a) The receiver operating characteristic (ROC) curves of the HOP score and the traditional New York Heart Association functional classification (NYHA Fc) in discriminating CPET-defined <svg height="10.4277pt" id="M81" style="vertical-align:-1.1198pt" version="1.1" viewbox="-0.0498162 -9.3079 103.881 10.4277" width="103.881pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M54 437L27 408L31 397H101V103C101 37 94 32 30 26V0H266V25C187 33 180 36 180 110V397H288C299 404 304 428 298 437H180V477C179 562 190 610 203 630C214 647 230 659 256 659C289 659 318 641 337 622C346 612 355 612 364 619C374 627 380 635 383 643C388 655 387 667 378 678C362 697 333 710 299 712C260 707 225 689 189 659C135 613 119 563 112 541S101 490 101 458V437H54Z"></path></g><g transform="matrix(.013,0,0,-0.013,3.926,0)"><path d="M518 50L491 51C452 54 444 60 444 110V444C429 441 405 437 377 434C348 430 314 427 287 426V403L323 397C356 392 365 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(b) The HOP score discriminates CPET-defined functional classes II and III from class I with the optimal cutoff value set at 8.8. MET Fc: functional classification defined by metabolic equivalent (MET) as measured by CPET.</div>

Disease Markers

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Figure 1

Figure 1: Amino Acid-Based Metabolic Profile Provides Functional Assessment and Prognostic Value for Heart Failure Outpatients 