Research Article

Oxidative Stress in Animal Models of Acute and Chronic Renal Failure

Table 1

Correlation coefficients (Spearman) between plasma markers, thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), fructosamine, total antioxidant capacity (TAC), and ferric reducing antioxidant power (FRAP), and urinary markers, TBARS, AOPP, fructosamine, FRAP, plasma creatinine, blood urea nitrogen (BUN), urinary kidney injury molecule-1 (uKIM-1), plasma kidney injury molecule-1 (pKIM-1), albumin/creatinine ratio of urine (ACR), and albuminuria in 5/6 nephrectomised (CKD model) and sham rats.

Plasma creatinine (μmol/l)BUN (mmol/l)pKIM-1 (pg/ml)uKIM-1 (pg/ml)ACR (g/mol)Albuminuria (mg/day)

Plasma markers of OS
TBARS (μmol/g)-0.42 n.s.-0.38 n.s.0.06 n.s.-0.30 n.s.0.33 n.s.0.39 n.s.
AOPP (μmol/g)-0.12 n.s.0.05 n.s-0.15 n.s.-0.05 n.s.-0.07 n.s.-0.08 n.s.
AGEs (g/g)-0.60-0.38 n.s.-0.38 n.s.-0.62-0.32 n.s-0.11 n.s.
Fructosamine (mmol/g)0.10 n.s.0.17 n.s.-0.43 n.s.-0.05 n.s.-0.06 n.s.0.07 n.s.
TAC (μmol/g)0.01 n.s.0.10 n.s.0.28 n.s.0.17 n.s.0.0 n.s.-0.08 n.s.
FRAP (μmol/g)0.07 n.s.0.10 n.s.0.06 n.s.0.12 n.s.0.14 n.s.0.12 n.s.
Urinary markers of OS
TBARS (μmol/mmol)0.23 n.s.0.44 n.s.-0.06 n.s.0.26 n.s.0.30 n.s.0.01 n.s.
AOPP (μmol/mmolg)0.23 n.s.0.06 n.s.0.38 n.s.0.700.51 n.s.-0.10 n.s.
Fructosamine (mmol/mmol)-0.31 n.s.-0.32 n.s.0.13 n.s.0.17 n.s.0.720.62
FRAP (μmol/mmol)-0.33 n.s.-0.28 n.s.0.49 n.s.0.32 n.s.0.820.69

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