Promoter Hypomethylation Is Responsible for Upregulated Expression of HAI-1 in Hepatocellular Carcinoma

Table 2

Frequency of HAI-1 CpG island hypomethylation in hepatocellular carcinomas and their association with clinical variables.

Variables		HAI-1 methylation status		value
		Hypomethylation ()	Hypermethylation ()
Gender	Male	7	6	0.155
	Female	0	2
Age (years)	<58	4	6	0.464
	≥58	3	2
Tumor size (cm)	<5	1	4	0.143
	≥5	6	4
Tumor number	Single	7	6	0.155
	Multiple	0	2
Liver cirrhosis	No	4	1	0.067
	Yes	3	7
HBV infection	No	3	2	0.464
	Yes	4	6
Vascular invasion	No	5	7	0.438
	Yes	2	1
Differentiation	High	0	5	0.031
	Moderate^1	4	1	0.010
	Poor^2	3	2	0.038
TNM stage	I+II+IIIA/B	6	7	0.919
	IIIC+IV	1	1

¹High differentiation vs. moderate differentiation. ²High differentiation vs. poor differentiation.