Research Article

Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration

Table 3

Genotype and allele frequencies of CFI rs10033900, ERCC6 rs3793784, VEGFA rs833068, HTRA1 rs11200638, TIMP3 rs9621532, and KCTD10 rs56209061 SNPs in early and exudative AMD and control groups.

Gene/markerGenotype/alleleEarly AMD (, %)Control group (, %) valueExudative AMD (, %)Control group (, %) value

CFI rs10033900CC64 (20.7)85 (27.8)83 (27.6)85 (27.8)
CG166 (53.7)148 (48.4)0.122151 (50.2)148 (48.4)0.874
GG79 (25.6)73 (23.9)67 (22.3)73 (23.9)
C0.480.520.1240.530.520.808
G0.520.480.470.48

ERCC6 rs3793784GG124 (40.1)117 (38.2)111 (36.9)117 (38.2)
GC128 (41.4)158 (51.6)0.004131 (43.5)158 (51.6)0.003
CC57 (18.4)31 (10.1)59 (19.6)31 (10.1)
G0.610.640.2450.590.640.053
C0.390.360.410.36

VEGFA rs833068GG191 (61.8)170 (55.6)185 (61.5)170 (55.6)
GA98 (31.7)119 (38.9)0.17593 (30.9)119 (38.9)0.096
AA20 (6.5)17 (5.6)23 (7.6)17 (5.6)
G0.780.750.2710.770.750.436
A0.220.250.230.25

HTRA1 rs11200638GG135 (43.7)161 (52.6)70 (23.3)161 (52.6)
GA129 (41.7)119 (38.9)0.021134 (44.5)119 (38.9)<0.001
AA45 (14.6)26 (8.5)97 (32.2)26 (8.5)
G0.650.720.0050.460.72<0.001
A0.350.280.540.28

TIMP3 rs9621532AA263 (85.1)269 (87.9)260 (86.4)269 (87.9)
AC41 (13.3)36 (11.8)0.21840 (13.3)36 (11.8)0.851
CC5 (1.6)1 (0.3)1 (0.3)1 (0.3)
A0.920.940.2660.930.940.590
C0.080.060.070.06

KCTD10 rs56209061GG268 (86.7)230 (75.2)253 (84.1)230 (75.2)
GA39 (12.6)71 (23.2)0.00146 (15.3)71 (23.2)0.021
AA2 (0.6)5 (1.6)2 (0.7)5 (1.6)
G0.930.87<0.0010.920.870.006
A0.070.130.080.13

AMD: age-related macular degeneration; values < 0.008 indicated in bold are statistically significant.