Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration
Table 3
Genotype and allele frequencies of CFI rs10033900, ERCC6 rs3793784, VEGFA rs833068, HTRA1 rs11200638, TIMP3 rs9621532, and KCTD10 rs56209061 SNPs in early and exudative AMD and control groups.
Gene/marker
Genotype/allele
Early AMD (, %)
Control group (, %)
value
Exudative AMD (, %)
Control group (, %)
value
CFI rs10033900
CC
64 (20.7)
85 (27.8)
83 (27.6)
85 (27.8)
CG
166 (53.7)
148 (48.4)
0.122
151 (50.2)
148 (48.4)
0.874
GG
79 (25.6)
73 (23.9)
67 (22.3)
73 (23.9)
C
0.48
0.52
0.124
0.53
0.52
0.808
G
0.52
0.48
0.47
0.48
ERCC6 rs3793784
GG
124 (40.1)
117 (38.2)
111 (36.9)
117 (38.2)
GC
128 (41.4)
158 (51.6)
0.004
131 (43.5)
158 (51.6)
0.003
CC
57 (18.4)
31 (10.1)
59 (19.6)
31 (10.1)
G
0.61
0.64
0.245
0.59
0.64
0.053
C
0.39
0.36
0.41
0.36
VEGFA rs833068
GG
191 (61.8)
170 (55.6)
185 (61.5)
170 (55.6)
GA
98 (31.7)
119 (38.9)
0.175
93 (30.9)
119 (38.9)
0.096
AA
20 (6.5)
17 (5.6)
23 (7.6)
17 (5.6)
G
0.78
0.75
0.271
0.77
0.75
0.436
A
0.22
0.25
0.23
0.25
HTRA1 rs11200638
GG
135 (43.7)
161 (52.6)
70 (23.3)
161 (52.6)
GA
129 (41.7)
119 (38.9)
0.021
134 (44.5)
119 (38.9)
<0.001
AA
45 (14.6)
26 (8.5)
97 (32.2)
26 (8.5)
G
0.65
0.72
0.005
0.46
0.72
<0.001
A
0.35
0.28
0.54
0.28
TIMP3 rs9621532
AA
263 (85.1)
269 (87.9)
260 (86.4)
269 (87.9)
AC
41 (13.3)
36 (11.8)
0.218
40 (13.3)
36 (11.8)
0.851
CC
5 (1.6)
1 (0.3)
1 (0.3)
1 (0.3)
A
0.92
0.94
0.266
0.93
0.94
0.590
C
0.08
0.06
0.07
0.06
KCTD10 rs56209061
GG
268 (86.7)
230 (75.2)
253 (84.1)
230 (75.2)
GA
39 (12.6)
71 (23.2)
0.001
46 (15.3)
71 (23.2)
0.021
AA
2 (0.6)
5 (1.6)
2 (0.7)
5 (1.6)
G
0.93
0.87
<0.001
0.92
0.87
0.006
A
0.07
0.13
0.08
0.13
AMD: age-related macular degeneration; values < 0.008 indicated in bold are statistically significant.