Research Article

Proximal Gastrectomy versus Total Gastrectomy for Siewert Type II Adenocarcinoma of the Esophagogastric Junction: A Comprehensive Analysis of Data from the SEER Registry

Table 2

Univariate and multivariate analyses for 1,254 AEG patients.

CharacteristicsUnivariate analysisMultivariate analysis
HR [95% CI]HR [95% CI]

Age<65 years1<0.011<0.01
≥65 years1.509 [1.296-1.758]1.650 [1.412-1.928]
Marital statusMarried10.00110.003
Others1.329 [1.126-1.568]1.292 [1.093-1.527]
GradeWell/moderately1<0.0110.017
Poorly/undifferentiated1.486 [1.267-1.743]1.220 [1.036-1.436]
AJCC stageStage IA1<0.011<0.01
Stage IB2.391 [1.738-3.288]<0.012.121 [1.528-2.942]<0.01
Stage II3.146 [2.349-4.212]<0.012.318 [1.576-3.408]<0.01
Stage IIIA3.716 [2.734-5.051]<0.012.283 [1.467-3.555]<0.01
Stage IIIB3.706 [2.428-5.655]<0.011.837 [1.022-3.302]0.042
AJCC N stageN01<0.011<0.01
N12.022 [1.690-2.419]<0.011.447 [1.096-1.911]0.009
N22.601 [2.067-3.274]<0.012.429 [1.620-3.641]<0.01
SurgeryProximal gastrectomy10.13910.012
Total gastrectomy1.121 [0.963-1.305]1.216 [1.043-1.418]
Regional lymph nodes examined1-10 nodes1<0.011<0.01
11-20 nodes0.743 [0.624-0.884]0.0010.635 [0.532-0.759]<0.01
>20 nodes0.651 [0.533-0.794]<0.010.530 [0.431-0.651]<0.01
Year2004-200910.0200.266
2010-20140.815 [0.687-0.968]
AJCC T stageT11<0.010.963
T22.285 [1.814-2.879]<0.010.963
T32.213 [1.699-2.881]<0.010.963
Tumor size (mm)1-201<0.010.289
21-501.713 [1.341-2.188]<0.010.679
>502.171 [1.684-2.800]<0.010.205
GenderMale10.726
Female0.815 [0.687-0.968]
RaceWhite10.464
Black1.021 [0.751-1.388]0.896
Others0.858 [0.670-1.098]0.224
ChemotherapyNo/unknown10.632
Yes0.963 [0.823-1.125]
RadiationNone/unknown10.584
Beam radiation0.958 [0.823-1.116]
Neoadjuvant radiationNone/unknown10.875
Yes0.989 [0.862-1.135]