Research Article
Diagnostic Accuracy of circRNAs in Esophageal Cancer: A Meta-Analysis
Table 2
Detailed information of overall meta-analysis and subgroup analyses.
| | Analysis | No. of studies | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | TP | FP | FN | TN |
| | Overall | 5 | 0.79 (0.69-0.87) | 0.85 (0.68-0.94) | 5.27 (2.46-11.32) | 0.24 (0.16-0.36) | 21.66 (9.33-50.30) | 154 | 32 | 43 | 146 | | Sample size | | | | | | | | | | | | ≥70 | 2 | 0.78 (0.69-0.86) | 0.86 (0.78-0.92) | 5.29 (3.26-8.59) | 0.21 (0.05-0.93) | 30.04 (12.83-70.33) | 78 | 14 | 22 | 86 | | <70 | 3 | 0.78 (0.69-0.86) | 0.77 (0.66-0.68) | 5.00 (0.89-28.03) | 0.28 (0.19-0.42) | 16.59 (3.49-78.98) | 76 | 18 | 21 | 60 | | circRNA expression | | | | | | | | | | | | Upregulated | 2 | 0.78 (0.67-0.88) | 0.68 (0.54-0.80) | 2.94 (0.70-12.41) | 0.32 (0.19-0.52) | 9.19 (2.28-37.04) | 51 | 17 | 14 | 36 | | Downregulated | 3 | 0.78 (0.70-0.85) | 0.88 (0.81-0.93) | 6.42 (3.28-12.59) | 0.23 (0.10-0.50) | 34.55 (15.65-76.27) | 103 | 15 | 29 | 110 |
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95% CI: 95% confidence interval; PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; TP: true positive; FP: false positive; FN: false negative; TN: true negative.
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