The Accuracy of Single MicroRNAs in Peripheral Blood to Diagnose Ovarian Cancer: An Updated Meta-Analysis

Table 1

Characteristics of included studies.

Author	Year	Country	Specimen	Control group	miRNA as biomarker	Case size	Control size	miRNA as control	Relative expression	SEN	SPE	TP	FP	FN	TN
Wang et al. [7]	2019	China	Serum	HP	miR-200c	110	116	miR-103	High	0.809	0.517	89	56	21	60
Wang et al. [7]	2019	China	Serum	HP	miR-205	110	116	miR-103	High	0.764	0.526	84	55	26	61
Kim et al. [8]	2019	Korea	Serum exosome	PBOD	miR-200c	48	20	RNU48	High	0.729	0.9	35	2	13	18
Kim et al. [8]	2019	Korea	Serum exosome	PBOD	miR-145	48	20	RNU48	High	0.917	0.868	44	3	4	17
Márton et al. [9]	2019	Hungary	Plasma	HP	miR-200a	28	60	miR-103	High	0.857	0.783	24	13	4	47
Márton et al. [9]	2019	Hungary	Plasma	HP	miR-200b	28	60	miR-103	High	0.679	0.9	19	6	9	54
Márton et al. [9]	2019	Hungary	Plasma	HP	miR-200c	28	60	miR-103	High	0.714	0.867	20	8	8	52
Márton et al. [9]	2019	Hungary	Plasma	HP	miR-141	28	60	miR-103	High	0.857	0.9	24	6	4	54
Márton et al. [9]	2019	Hungary	Plasma	HP	miR-429	28	60	miR-103	High	0.857	0.683	24	19	4	41
Zuberi et al. [10]	2019	India	Serum	HP	miR-145	70	70	RNU6B	Low	0.991	0.957	69	3	1	67
Meng et al. [11]	2016	Germany	Serum	HP	miR-200a	60	32	miR-484	High	0.672	0.9	40	3	20	29
Meng et al. [11]	2016	Germany	Serum	HP	miR-200b	60	32	miR-484	High	0.931	0.9	56	3	4	29
Meng et al. [11]	2016	Germany	Serum	HP	miR-200c	60	32	miR-484	High	0.845	0.85	51	5	9	27
Zhu et al. [12]	2017	China	Serum	PBOD	miR-125b	135	54	miR-16	High	0.756	0.685	102	17	33	37
Zuberi et al. [13]	2016	India	Serum	HP	miR-125b	70	70	RNU6	High	0.623	0.771	44	16	26	54
Meng et al. [14]	2015	Germany	Serum	HP	miR-429	180	66	miR-484	High	0.594	0.955	107	3	73	63
Gao and Wu [15]	2015	China	Serum	HP	miR-141	93	50		High	0.69	0.72	64	14	29	36
Gao and Wu [15]	2015	China	Serum	HP	miR-200c	93	50		High	0.72	0.7	67	15	26	35
Zheng et al. [16]	2013	China	Plasma	HP	miR-205	134	70		High	0.301	0.942	40	4	94	66
Kan et al. [17]	2012	Australia	Serum	HP	miR-200a	28	28	miR-103	High	0.857	0.357	24	18	4	10
Kan et al. [17]	2012	Australia	Serum	HP	miR-200b	28	28	miR-103	High	0.857	0.357	24	18	4	10
Kan et al. [17]	2012	Australia	Serum	HP	miR-200c	28	28	miR-103	High	0.714	0.571	20	12	8	16

Abbreviation: HP—healthy people; PBOD—patients with benign ovarian disease; SEN—sensitivity; SPE—specificity; TP—true positive; FP—false positive; FN—false negative; TN—true negative. Relative expression for microRNA as a biomarker of the case group compared to the control group.