Research Article
The Accuracy of Single MicroRNAs in Peripheral Blood to Diagnose Ovarian Cancer: An Updated Meta-Analysis
Table 2
Diagnostic values of miRNAs for ovarian cancer.
| | MicroRNA | | SEN (95% CI) | SPE (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
| | miR-200a | 3 | 0.759 (0.670-0.833) | 0.717 (0.627-0.795) | 3.129 (0.997-9.816) | 0.301 (0.207-0.437) | 11.323 (3.493-36.711) | 0.857 | | miR-200b | 3 | 0.853 (0.776-0.912) | 0.775 (0.690-0.846) | 4.327 (0.683-27.415) | 0.225 (0.081-0.625) | 19.678 (2.812-137.72) | 0.90 | | miR-200c | 6 | 0.768 (0.722-0.811) | 0.680 (0.624-0.732) | 2.897 (1.787-4.698) | 0.340 (0.276-0.417) | 8.917 (4.521-17.587) | 0.815 | | miR-205 | 2 | 0.508 (0.444-0.573) | 0.683 (0.611-0.749) | 2.675 (0.740-9.672) | 0.590 (0.310-1.122) | 4.359 (2.716-6.996) | | | miR-145 | 2 | 0.958 (0.904-0.986) | 0.933 (0.861-0.975) | 11.711 (3.108-44.130) | 0.043 (0.004-0.461) | 278.62 (11.704-6632.9) | | | miR-141 | 2 | 0.727 (0.639-0.804) | 0818 (0.733-0.885) | 4.411 (1.298-14.988) | 0.281 (0.093-0.856) | 16.279 (1.797-147.47) | | | miR-429 | 2 | 0.630 (0.560-0.696) | 0.825 (0.748-0.887) | 5.700 (0.618-52.568) | 0.331 (0.148-0.736) | 21.999 (9.595-50.438) | | | miR-125b | 2 | 0.712 (0.645-0.773) | 0.734 (0.647-0.809) | 2.539 (1.870-3.447) | 0.420 (0.331-0.533) | 6.219 (3.819-10.127) | |
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Abbreviation: SEN—sensitivity; SPE—specificity; PLR—positive likelihood ratio; NLR—negative likelihood ratio; DOR—diagnostic odds ratio; AUC—area under curve; CI—confidence interval.
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