Research Article

Prognostic and Clinicopathological Significance of PD-L1 in Patients with Cholangiocarcinoma: A Meta-Analysis

Table 2

Immunohistochemical technique used in the studies included in the meta-analysis.

AuthorYearDetection methodPrimary antibodySourceCut-off value
AntibodySpecieCloneDilution

Ahn, S.2019IHCAnti-PD-L1Mouse, MAB22C31 : 100Dako, Carpinteria, CA, USA1%
Arkenau, H. T.2018IHCAnti-PD-L1Mouse, MAB22C3NRAgilent, Carpinteria, CA1%
Dong, Z. T.2020IHCAnti-PD-L1MABNRNRCell Signaling Technology, Inc. Danvers, MA, USA5%
Gani, F.2016IHCAnti-PD-L1Mouse, MAB5H1NRNR5%
Gou, M. M.2019IHCAnti-PD-L1NRNRNRNR1%
Jing, C. Y.2019IHCAnti-PD-L1Rabbit, MABE1L3N1 : 200Cell Signaling Technology, MA, USA5%
Kim, R.2018IHCAnti-PD-L1Mouse, MAB5H1NRNR1%
Kitano, Y.2020IHCAnti-PD-L1Rabbit, MABE1L3N1 : 200Cell Signaling Technology, Tokyo, Japan5%
Kriegsmann, M.2019IHCAnti-PD-L1NRSP263NRRoche AG, Rotkreuz, Switzerland1%
Lim, Y. J.2015IHCAnti-PD-L1Rabbit, MABE1L3N1 : 100Cell Signaling Technology, Danvers, MA, USAH-score 5
Lu, J. C.2019IHCAnti-PD-L1Rabbit, MABSP1421 : 100GeneTech Co. Ltd., Shanghai, China5%
Ma, K.2017IHCAnti-PD-L1Rabbit, MABNR1 : 250Abcam, Cambridge, MA, USA5%
Sangkhamanon, S.2017IHCAnti-PD-L1NRNR1 : 1000Roche Diagnostic GmbH, USA1%
Tamai, K.2014IHCAnti-CD274Rabbit, PABNRNRAbcam, Cambridge, MA, USA++
Ueno, T.2018IHCAnti-PD-L1NRNRNRNR5%
Walter, D.2017IHCAnti-PD-L1Rabbit, MABE1L3N1 : 50Cell Signaling Technology, Danvers, MA, USAScore 3
Yu, F.2019IHCAnti-PD-L1Rabbit, MABE1L3N1 : 200Cell Signaling Technology, Danvers, MA, USAScore 3
Zhu, Y.2018IHCAnti-PD-L1Rabbit, MABSP1421 : 50Spring Bioscience, Inc., CA, USA5%

MAB: monoclonal antibody; IHC: immunohistochemistry; NR: not reported; PAB: polyclonal antibody.