KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway
Knockdown of KIF20A inhibits CRC cell proliferation and migration ability through the JAK/STAT3 signaling pathway. (a) Cell proliferation activity after knockdown of KIF20A was assessed by CCK-8 assay. (b) Cell wound closure ability was analyzed by wound healing assay. (c) Transwell analysis was used to determine cell migration ability with or without KIF20A knockdown. Statistical significance was analyzed according to the number of migrated cells. (d) MMP2, phosphorylation of JAK, and STAT3 expression after KIF20A knockdown were determined by Western blot analysis. Data are presented as the .;.
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