Prognostic Role of Serum Amino Acids in Head and Neck Cancer

Table 3

Predictors of OS among 202 HNC cases by multivariate analysis.

Amino acid	HRs (95% CI)^a	value
Alanine	0.64 (0.35-1.15)	0.135
Alpha-aminobutyric acid	0.41 (0.24-0.69)	0.001
Aminoadipic acid	1.13 (0.65-1.94)	0.671
Arginine	2.13 (1.07-4.24)	0.030
Asparagine	2.76 (0.99-7.74)	0.053
Beta-alanine	0.70 (0.35-1.40)	0.309
Beta-aminobutyric acid	1.04 (0.63-1.72)	0.882
Citrulline	0.65 (0.39-1.08)	0.099
Ethanolamine	2.28 (1.07-4.84)	0.032
Gamma-aminobutyric acid	nc	nc
Glycine	2.49 (1.17-5.32)	0.018
Histidine	2.98 (1.44-6.19)	0.003
Isoleucine	3.08 (1.49-6.40)	0.002
4-Hydroxyproline	1.66 (1.00-2.74)	0.048
Leucine	2.29 (1.17-4.48)	0.015
Lysine	2.34 (1.19-4.60)	0.014
Methionine	1.40 (0.85-2.31)	0.189
1-Methylhistidine	0.59 (0.35-1.00)	0.050
3-Methylhistidine	1.83 (1.07-3.13)	0.027
Ornithine	1.56 (0.93-2.63)	0.091
Phenylalanine	2.06 (1.19-3.57)	0.010
Phosphoethanolamine	nc	nc
Proline	1.63 (0.92-2.88)	0.092
Sarcosine	1.54 (0.91-2.62)	0.107
Serine	2.71 (1.39-5.31)	0.004
Threonine	0.67 (0.41-1.11)	0.121
Tryptophan	0.68 (0.39-1.19)	0.175
Tyrosine	1.52 (0.82-2.82)	0.187
Valine	1.30 (0.74-2.29)	0.360

^aHazard ratio adjusted for age, sex, stage, treatment type, smoking status, and alcohol drinking status; nc: not computable.