Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

Table 2

Univariate and multivariate Cox regression analyses of risk factors for overall survival rate ().

			Univariate analysis			Multivariate analysis
		OS (%)	HR	95% CI	value	HR	95% CI	value
Age	<50 ()	87 (69.6%)	1.060	0.714–1.573	0.773
	≥50 ()	142 (67.0%)
Gender	Female ()	53 (70.7%)	1.231	0.770-1.967	0.385
	Male ()	176 (67.2%)
Liver cirrhosis	Absent ()	15 (60%)	1.420	0.740-2.722	0.291
	Present ()	214 (68.6%)
AFP	<20 ()	118 (72.0%)	1.269	0.866-1.860	0.222
	≥20 ()	111 (64.2%)
Tumor multiplicity	Single ()	174 (67.4%)	1.095	0.916-1.209	0.696
	Multiple ()	55 (69.6%)
Maximal tumor size	<5 cm ()	127 (66.8%)	1.063	0.638-1.174	0.756
	≥5 cm ()	102 (69.4%)
Pathologic TNM stage	I/II ()	196 (74.0%)	3.136	2.112-4.658	<0.001	3.161	2.129-4.695	<0.001
	III/IV ()	33 (45.8%)
FEN1 level	Low ()	126 (72.8%)	1.881	1.066-2.285	0.022	1.585	1.083-2.320	0.018
	High ()	103 (62.8%)