CD26-Related Serum Biomarkers: sCD26 Protein, DPP4 Activity, and Anti-CD26 Isotype Levels in a Colorectal Cancer-Screening Context

Table 3

Levels of serum DPP-IV activity, sCD26 concentration, and anti-CD26/DPP-IV autoantibody isotypes according to the colonoscopy result in FIT-positive individuals.

Colonoscopy finding	DPP4; (mU/mL)			sCD26; (ng/mL)			IgA; (Abs450nm)			IgG; (Abs450nm)			IgM; (Abs450nm)
			value^1			value^1			value^1			value^1			value^1
NCF	7			8			8			8			8
BP	12			12			11			11			11
HP	6		0.924	6		0.903	6		0.899	6		0.408	6		0.484
AD	20		0.227	20		0.808	19		0.365	19		0.184	19		0.439
CRC	1	40.52		1	605.93		1	0.21		1	0.34		1	0.003
NCF+BP+HP	25			26			25			25			25
AD+CRC	21		0.221^2	21		0.898^2	20		0.309^2	20		0.083^2	20		0.385^2

NCF: no colorectal finding; BP: benign pathology; HP: hyperplastic polyp; AD: adenomas; CRC: colorectal cancer; ¹Mann-Whitney test for comparison of NCF+BP vs. the other groups; ²Mann-Whitney test for comparison of NCF+BP+HP vs. AD+CRC.