Disease Markers / 2020 / Article / Fig 6

Research Article

6,12-Diphenyl-3, 9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate Inhibits Proliferation, Migration and Promotes Apoptosis in Ovarian Cancer Cells

Figure 6

The effect of DDTC on the expression of caspase 3, cleaved caspase 3, caspase 9, and cleaved caspase 9. The dosage of DDTC at 0.1 μM, 1 μM, and 10 μM in SKOV3 and A2780 cells. (a, b) Western blot assay showed that DDTC downregulated the expression of caspase 3 and caspase 9 protein levels and upregulated the expression of cleaved caspase 3 and cleaved caspase 9 protein levels in SKOV3 cells andA2780 cells. (c, d) Western blot assay showed that DDTC downregulated the expression of caspase 3 and caspase 9 protein levels and upregulated the expression of cleaved caspase 3 and cleaved caspase 9 protein levels in A2780 cells. (e) The mRNA levels of caspase 3 and caspase 9 were decreased, and levels of cleaved caspase 3 and cleaved caspase 9 were increased in SKOV3 cells by Q-PCR. (f) The mRNA levels of caspase 3 and caspase 9 were decreased and levels of cleaved caspase 3 and cleaved caspase 9 were increased in A2780 cells by Q-PCR. ; vs. the control group.
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