Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer
Table 2
Cox’s univariate regression analysis of the patient survival in breast cancer with respect to clinical parameters and cancer biological factors.
Variables
a
DFS HR (95% CI)b
OS HR (95% CI)b
Age (years)
0.508
0.747
≤50
131
1
1
>50
85
1.131 (0.786-1.627)
0.900 (0.475-1.706)
Tumor size (cm)
0.680
0.164
≤2
103
1
1
>2
113
1.079 (0.751-1.552)
1.627 (0.819-3.232)
Lymph node status
<0.001
0.015
Negative
120
1
1
Positive
96
2.125 (1.483-3.045)
2.248 (1.170-4.318)
Menopausal
0.299
0.358
Premenopausal
112
1
1
Postmenopausal
104
0.828 (0.580-1.182)
0.741 (0.390-1.404)
ER status
0.714
0.237
Negative
160
1
1
Positive
56
0.927 (0.616-1.393)
0.610 (0.268-1.385)
PR status
0.703
0.780
Negative
159
1
1
Positive
57
0.924 (0.615-1.389)
0.902 (0.438-1.858)
HER2 status
0.001
0.001
Negative
91
1
1
Positive
125
1.925 (1.307-2.835)
4.142 (1.731-9.909)
SGLT1
0.003
0.011
Negative
100
1
1
Positive
116
1.738 (1.208-2.500)
2.402 (1.225-4.711)
Significant values () are indicated in bold. aNumber of patients. bHazard ratio (HR) (CI confidence interval) of Cox’s univariate regression analysis.
