Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors

Figure 3

The relationship between the preoperative serum occludin level and the peritumoral brain edema (PTBE) before surgery. (a) Pearson’s correlation analysis showing that the preoperative serum occludin level was significantly positively correlated with the extent of the preoperative PTBE as measured by the vertical distance from the outer edge of the maximal edema zone to the tumor boundary (). (b) Preoperative serum occludin levels for the various Steinhoff grades of PTBE. Data are presented as (grade 0, ; grade I, ; grade II, ; and grade III, ). vs. grade 0; ^# vs. grade I; and ^$ versus grade II. (c) Pearson’s correlation analysis showing that the preoperative serum occludin level was not significantly correlated with the tumor diameter. (d) Receiver operating characteristic curve for the ability of the serum occludin level to distinguish between mild and severe PTBE. AUC: area under the curve; CI: confidence interval.

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