Disease Markers / 2020 / Article / Tab 1

Review Article

Updating a Strategy for Histone Deacetylases and Its Inhibitors in the Potential Treatment of Cerebral Ischemic Stroke

Table 1

Primary HDAC and HDAC inhibitors in cerebral ischemia.

HDAC classificationHDAC inhibitorsLocation

Zinc-dependent class IHDAC 1MS-275, FK-288, TSA, VPA, ScriptaidNU
HDAC 2FK-288, SAHA, SB, ScriptaidNU
HDAC 3MGCD0103, ScriptaidNU/CM
HDAC 8/NU/CM

Zinc-dependent class II (class IIa)HDAC 4TSA, 4-PBANU/CM
HDAC 5/NU/CM
HDAC 7/NU/CM
HDAC 9/NU/CM

Zinc-dependent class II (class IIb)HDAC 6Tubacin, SAHACM

NAD+-dependent class III (sirtuins)SIRT1SirtinolNU
SIRT2AKG2NU/CM
SIRT3/Mitochondria

NU: nucleus; CM: cytoplasm.

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