Updating a Strategy for Histone Deacetylases and Its Inhibitors in the Potential Treatment of Cerebral Ischemic Stroke

Table 1

Primary HDAC and HDAC inhibitors in cerebral ischemia.

HDAC classification		HDAC inhibitors	Location
Zinc-dependent class I	HDAC 1	MS-275, FK-288, TSA, VPA, Scriptaid	NU
	HDAC 2	FK-288, SAHA, SB, Scriptaid	NU
	HDAC 3	MGCD0103, Scriptaid	NU/CM
	HDAC 8	/	NU/CM
Zinc-dependent class II (class IIa)	HDAC 4	TSA, 4-PBA	NU/CM
	HDAC 5	/	NU/CM
	HDAC 7	/	NU/CM
	HDAC 9	/	NU/CM
Zinc-dependent class II (class IIb)	HDAC 6	Tubacin, SAHA	CM
NAD^+-dependent class III (sirtuins)	SIRT1	Sirtinol	NU
	SIRT2	AKG2	NU/CM
	SIRT3	/	Mitochondria

NU: nucleus; CM: cytoplasm.