Cardiopulmonary Bypass Induces Acute Lung Injury via the High-Mobility Group Box 1/Toll-Like Receptor 4 Pathway

Figure 1

CPB induced TLR4 and HMGB1 expression in the lung tissues. (a) Western blot showing the TLR4 protein expression in the lung tissues of the control and CPB groups. (b) TLR4 protein density relative to that of β-actin. The TLR4 protein level was significantly higher in the CPB group than in the control group (a, b). (c) Western blot showing the HMGB1 protein expression of lung tissues in the control and CPB groups. (d) The HMGB1 protein density relative to that of β-actin. (e) The concentrations of HMGB1 were evaluated by ELISAs. HMGB1 protein level is much higher in the CPB group than in the control group by using western blot and ELISAs (c–e). Data are represented as the , per group. vs. the control.

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