TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia

Table 2

Association of TGFBR3 rs1805110 and rs7526590 polymorphism with clinical manifestation in SCA.

Clinical manifestation	Polymorphisms
	rs1805110		value	rs7526590		value
	GG ()	AG+AA ()		AA ()	AT+TT ()
Acute chest syndrome	19	12	0.259	22	9	0.797
Bone alterations	3	7	0.006	7	3	1.000
Cholelithiasis	27	9	0.661	26	10	0.609
Infections	60	22	0.540	52	30	0.232
Leg ulcer	9	2	0.506	4	7	0.037
Pneumonia	42	24	0.086	47	19	0.444
Painful crises	48	25	0.186	53	20	0.197
Splenomegaly	34	21	0.072	38	17	0.883
Stroke	8	4	0.744	9	3	0.749
Vaso-occlusive events	28	14	0.598	28	14	0.951

Bold values indicate significance at . All values obtained by the chi-squared test, except for those with asterisk (), for which the Fisher exact test was used.