Research Article

Identification of Differential Intestinal Mucosa Transcriptomic Biomarkers for Ulcerative Colitis by Bioinformatics Analysis

Table 2

Gene ontology analysis of 18 central hub genes in UC.

CategoryTermCount valueGenes--log10 ( value)

GOTERM_BP_DIRECTGO:0070098~chemokine-mediated signaling pathway78.79E-12CCL20, CXCL2, CXCR1, CXCL8, CXCL11, CXCL107.977397
GOTERM_BP_DIRECTGO:0006954~inflammatory response83.40E-09CCL20, PTGS2, CXCL2, CXCL8, NOS2, CXCL11, CXCL105.389683
GOTERM_BP_DIRECTGO:0042127~regulation of cell proliferation71.41E-08PTGS2, CXCL2, CXCL8, NOS2, CXCL11, CXCL104.772917
GOTERM_BP_DIRECTGO:0006955~immune response71.42E-07CXCL2, IL1B, CXCL8, CXCL11, IL1A, CXCL103.770405
GOTERM_BP_DIRECTGO:0006935~chemotaxis53.20E-07CCL20, CXCR1, CXCL11, CXCL103.415649
GOTERM_BP_DIRECTGO:0032496~response to lipopolysaccharide52.71E-06CXCL2, CXCL8, CXCL11, CXCL102.488617
GOTERM_BP_DIRECTGO:0060326~cell chemotaxis42.42E-05CCL20, CXCL2, CXCL10, ICAM1,1.537263
GOTERM_CC_DIRECTGO:0005615~extracellular space131.26E-11CCL20, MMP9, IL1RN, CXCL2, IL1B, CXCL8,CXCL11,SELE,IL1A, CXCL10, TIMP17.981942
GOTERM_MF_DIRECTGO:0008009~chemokine activity67.11E-10CCL20, CXCL2, CXCL8, CXCL11, CXCL106.189676
GOTERM_MF_DIRECTGO:0045236~CXCR chemokine receptor binding42.98E-07CXCL2, CXCL8, CXCL103.567109