Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

Table 3

Main outcomes of the analyses on periodontitis and TLR-2 rs3804100 (T>C) polymorphism.

Model	Subgroup	No. of studies	Case/control	OR	95% CI		Pooling model
T vs. C	Overall (fulfill HWE)	4	2215/2202	0.922	0.797-1.065	65.6%	Random	0.269
	Caucasian	1	1502/1789	0.898	0.738-1.092	0	Fixed	0.282
	Asian	3	713/413	0.951	0.766-1.179	76.7%	Random	0.645
	CP	3	1580/1302	1.012	0.849-1.207	43.4%	Fixed	0.893
	AgP	2	635/900	0.713	0.474-1.072	51.5%	Random	0.104
TC+CC vs. TT	Overall (fulfill HWE)	4	2215/2202	1.047	0.718-1.528	63.9%	Random	0.812
	Caucasian	1	1502/1789	1.120	0.912-1.375	0	Fixed	0.280
	Asian	3	713/413	1.033	0.530-2.014	74.1%	Random	0.924
	CP	3	1580/1302	0.942	0.758-1.170	31.8%	Fixed	0.589
	AgP	2	635/900	1.511	0.854-2.672	55.3%	Random	0.156
CC vs. TC+TT	Overall (fulfill HWE)	4	2215/2202	1.188	0.839-1.681	0	Fixed	0.332
	Caucasian	1	1502/1789	1.192	0.344-4.124	0	Fixed	0.782
	Asian	3	713/413	1.187	0.827-1.705	23.3%	Fixed	0.352
	CP	3	1580/1302	1.129	0.778-1.637	0	Fixed	0.523
	AgP	2	635/900	1.706	0.667-4.363	0	Fixed	0.265
TC vs. TT	Overall (fulfill HWE)	4	2215/2202	1.012	0.700-1.463	57.2%	Random	0.948
	Caucasian	1	1502/1789	1.118	0.909-1.375	0	Fixed	0.293
	Asian	3	713/413	0.918	0.653-1.290	66.9%	Random	0.621
	CP	3	1580/1302	0.921	0.735-1.154	18.8%	Fixed	0.474
	AgP	2	635/900	1.332	0.999-1.777	31.6%	Fixed	0.051
CC vs. TT	Overall (fulfill HWE)	4	2215/2202	1.122	0.749-1.681	40.6%	Fixed	0.577
	Caucasian	1	1502/1789	1.208	0.349-4.183	0	Fixed	0.765
	Asian	3	713/413	1.112	0.725-1.706	60.3%	Random	0.626
	CP	3	1580/1302	0.997	0.641-1.550	0	Fixed	0.990
	AgP	2	635/900	2.203	0.806-6.023	35.1%	Fixed	0.124