Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

Table 5

Main outcomes of the analyses on periodontitis and TLR-2 rs5743708 (G>A) polymorphism.

Model	Subgroup	No. of studies	Case/control	OR	95% CI		Pooling model
G vs. A	Overall (fulfill HWE)	9	2361/2722	0.949	0.765-1.177	26.7%	Fixed	0.633
	Caucasian	7	2181/2522	0.881	0.707-1.099	0	Fixed	0.262
	Asian	2	180/200	12.064	1.570-92.688	0	Fixed	0.017
	CP	8	1520/1823	0.845	0.646-1.104	0	Fixed	0.216
	AgP	5	841/1080	1.149	0.805-1.640	17.7%	Fixed	0.444
GA+AA vs. GG	Overall (fulfill HWE)	9	2361/2722	1.041	0.834-1.298	28.6%	Fixed	0.724
	Caucasian	7	2181/2522	1.124	0.897-1.409	0	Fixed	0.311
	Asian	2	180/200	0.080	0.010-0.620	0	Fixed	0.016
	CP	8	1520/1823	1.179	0.896-1.551	0	Fixed	0.241
	AgP	5	841/1080	0.849	0.590-1.221	18.8%	Fixed	0.377
AA vs. GA+GG	Overall (fulfill HWE)	9	2361/2722	3.677	0.382-35.389	0	Fixed	0.260
	Caucasian	7	2181/2522	3.677	0.382-35.389	0	Fixed	0.260
	Asian	2	180/200	—	—	—	Fixed	—
	CP	8	1520/1823	2.529	0.229-27.935	0	Fixed	0.449
	AgP	5	841/1080	2.865	0.422-19.464	0	Fixed	0.442
GA vs. GG	Overall (fulfill HWE)	9	2361/2722	1.026	0.821-1.282	0	Fixed	0.820
	Caucasian	7	2181/2522	1.109	0.883-1.392	0	Fixed	0.374
	Asian	2	180/200	0.080	0.821-1.282	0	Fixed	0.016
	CP	8	1520/1823	1.166	0.885-1.538	0	Fixed	0.275
	AgP	5	841/1080	0.833	0.578-1.201	17.5%	Fixed	0.328
AA vs. GG	Overall (fulfill HWE)	9	2361/2722	3.692	0.384-35.538	0	Fixed	0.258
	Caucasian	7	2181/2522	3.692	0.384-35.538	0	Fixed	0.258
	Asian	2	180/200	—	—	—	Fixed	—
	CP	8	1520/1823	2.555	0.231-28.229	0	Fixed	0.444
	AgP	5	841/1080	2.878	0.424-19.560	0	Fixed	0.444