Ethacrynic Acid Enhances the Antitumor Effects of Afatinib in EGFR/T790M-Mutated NSCLC by Inhibiting WNT/Beta-Catenin Pathway Activation

Table 1

The coefficient index (CI) of afatinib combined with EA in NSCLC cells.

Drugs	A549 cell		H1975 cell
	Fa	CI	Fa	CI
Combination 1: Afatinib (2 μM) + EA (75 μM)	0.366151	1.362	0.883641	0.200
Combination 2: Afatinib (2 μM) + EA (100 μM)	0.465099	1.182	0.969724	0.114
Combination 3: Afatinib (6 μM) + EA (75 μM)	0.471219	1.830	0.93933	0.146
Combination 4: Afatinib (6 μM) + EA (100 μM)	0.730376	0.812	0.97684	0.101

CI: coefficient index; Fa: the fraction affected by dose; Fu: the unaffected fraction; .