Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

Table 5

Correlation of serum metabolites with severity of HDM-induced AR.

Metabolites	TNSS		VAS
		value		value
Sarcosine	0.551	0.012	0.376	0.040
Palmitic acid	0.489	0.137	0.413	0.107
Triethanolamine	-0.212	0.170	0.301	0.019
Betaine	0.431	0.049	0.298	0.202
5-Methoxyindoleacetate	-0.204	0.765	0.376	0.046
trans-Vaccenic acid	-0.312	0.031	-0.178	0.099
Creatinine	0.702	0.129	0.561	0.049
S1P	0.821	0.004	0.673	0.030
Phosphorylcholine	0.378	0.418	0.277	0.031
Cytidine	0.598	0.028	0.312	0.017
Diethanolamine	0.242	0.782	0.134	0.458
cis-9,10-Epoxystearic acid	0.366	0.232	-0.221	0.022
Taurocholic acid	-0.207	0.651	-0.319	0.562
Linoleic acid	-0.792	0.031	-0.493	0.041
Palmitoleic acid	-0.377	0.052	-0.274	0.093
Pyroglutamic acid	-0.134	0.202	-0.307	0.089

AR: allergic rhinitis; TNSS: total nasal symptom score; VAS: visual analogue scale; HDM: house dust mite; S1P: sphingosine-1-phosphate.