Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis

Table 3

Meta-analysis of the association between common SNPs and cancer risk.

Stratification		Heterozygote vs. wild-type			Mutation homozygote vs. wild-type			Dominant model			Recessive model			Allelic model
		OR (95% CI)		(%)	OR (95% CI)		(%)	OR (95% CI)		(%)	OR (95% CI)		(%)	OR (95% CI)		(%)
CYP2R1
rs10741657 (G/A)	6	0.987 (0.947-1.028)	0.522	0	1.006 (0.906-1.117)	0.905	50.9	0.995 (0.957-1.034)	0.799	18.4	1.030 (0.978-1.084)	0.264	41.2	0.998 (0.949-1.050)	0.943	51.2
Ethnicity
Caucasian	5	0.989 (0.948-1.031)	0.587	0	1.016 (0.905-1.142)	0.785	58.2	0.997 (0.959-1.038)	0.901	30.8	1.030 (0.936-1.133)	0.543	50.2	1.003 (0.948-1.061)	0.917	58.5
Asian	1	0.951 (0.786-1.152)	0.608	NA	0.918 (0.694-1.214)	0.547	NA	0.944 (0.787-1.131)	0.531	NA	0.943 (0.727-1.223)	0.658	NA	0.957 (0.840-1.089)	0.503	NA
Type of cancer
Breast cancer	2	0.963 (0.907-1.023)	0.227	0	1.008 (0.927-1.095)	0.858	20.7	0.974 (0.920-1.031)	0.361	0	1.030 (0.955-1.111)	0.442	14.9	0.995 (0.957-1.036)	0.817	31.1
Pancreas cancer 2	1	0.895 (0.726-1.103)	0.289	NA	0.698 (0.514-0.947)	0.021	NA	0.844 (0.693-1.029)	0.093	NA	0.740 (0.557-0.984)	0.038	NA	0.848 (0.736-0.978)	0.023	NA
Prostate cancer	1	1.024 (0.963-1.090)	0.445	NA	1.071 (0.984-1.165)	0.114	NA	1.036 (0.977-1.098)	0.236	NA	1.057 (0.978-1.142)	0.165	NA	1.033 (0.992-1.076)	0.118	NA
Hepatocellular carcinoma	1	0.951 (0.786-1.152)	0.608	NA	0.918 (0.694-1.214)	0.547	NA	0.944 (0.787-1.131)	0.531	NA	0.943 (0.727-1.223)	0.658	NA	0.957 (0.840-1.089)	0.503	NA
Thyroid caner	1	0.981 (0.679-1.416)	0.918	NA	1.324 (0.810-2.164)	0.263	NA	1.063 (0.755-1.499)	0.725	NA	1.338 (0.853-2.098)	0.205	NA	1.122 (0.881-1.429)	0.352	NA
Source of controls
HB	2	0.959 (0.903-1.018)	0.169	0	0.984 (0.905-1.070)	0.709	0	0.965 (0.912-1.021)	0.214	0	1.007 (0.933-1.088)	0.85	0	0.984 (0.946-1.024)	0.437	0
PB	4	1.012 (0.957-1.071)	0.677	0	1.020 (0.829-1.256)	0.849	64.6	1.022 (0.969-1.078)	0.415	23.5	1.032 (0.867-1.229)	0.723	60.7	1.007 (0.913-1.110)	0.89	62.3
rs12794714 (G/A)	4	1.007 (0.825-1.231)	0.942	51	0.908 (0.609-1.352)	0.634	68	0.993 (0.789-1.249)	0.953	66.2	0.907 (0.664-1.239)	0.539	58.9	0.968 (0.807-1.160)	0.723	72.5
Ethnicity
Caucasian	3	1.127 (0.951-1.336)	0.167	0	1.134 (0.921-1.397)	0.236	40.9	1.130 (0.964-1.326)	0.132	10.5	1.056 (0.881-1.265)	0.558	24.8	1.074 (0.967-1.192)	0.183	41.2
African	1	0.831 (0.672-1.028)	0.088	NA	0.432 (0.205-0.910)	0.027	NA	0.800 (0.650-0.985)	0.036	NA	0.457 (0.217-0.959)	0.039	NA	0.800 (0.666-0.960)	0.017	NA
Type of cancer
Colorectal cancer	2	0.862 (0.718-1.035)	0.111	0	0.681 (0.317-1.466)	0.326	69.1	0.841 (0.705-1.003)	0.054	0	0.717 (0.344-1.493)	0.374	68.9	0.866 (0.753-0.997)	0.046	44.1
Pancreas cancer	1	1.217 (0.973-1.524)	0.086	NA	1.336 (1.016-1.775)	0.038	NA	1.252 (1.014-1.546)	0.036	NA	1.185 (0.936-1.500)	0.157	NA	1.167 (1.017-1.339)	0.028	NA
Thyroid caner	1	1.088 (0.742-1.595)	0.666	NA	0.847 (0.522-1.377)	0.504	NA	1.014 (0.706-1.455)	0.94	NA	0.805 (0.526-1.230)	0.315	NA	0.939 (0.740-1.191)	0.604	NA
Source of controls
HB	1	0.956 (0.669-1.367)	0.806	NA	0.952 (0.617-1.469)	0.825	NA	0.955 (0.684-1.333)	0.787	NA	0.978 (0.671-1.427)	0.909	NA	0.973 (0.780-1.213)	0.806	NA
PB	3	1.023 (0.787-1.331)	0.864	66.9	0.856 (0.476-1.538)	0.602	78	1.004 (0.742-1.360)	0.978	77.3	0.839 (0.522-1.348)	0.468	72.5	0.963 (0.754-1.231)	0.765	81.6
rs2060793 (G/A)	2	1.121 (0.923-1.362)	0.247	0	1.184 (0.902-1.554)	0.223	19	1.136 (0.946-1.364)	0.172	0	1.113 (0.866-1.430)	0.402	6.3	1.098 (0.964-1.250)	0.16	8.4
DHCR7
rs12785878 (T/G)	5	1.168 (1.027-1.328)	0.018	8.3	1.074 (0.736-1.569)	0.71	73.1	1.136 (0.935-1.381)	0.2	53.2	1.017 (0.762-1.357)	0.91	67.5	1.064 (0.906-1.250)	0.448	70.1
Ethnicity
Caucasian	4	1.178 (1.021-1.358)	0.024	30.1	0.980 (0.562-1.710)	0.944	79.2	1.108 (0.854-1.436)	0.441	64.8	0.929 (0.584-1.477)	0.756	73.7	1.031 (0.814-1.305)	0.802	77.2
Asian	1	1.127 (0.836-1.520)	0.433	NA	1.252 (0.931-1.684)	0.136	NA	1.191 (0.898-1.579)	0.226	NA	1.139 (0.954-1.361)	0.15	NA	1.120 (0.980-1.281)	0.097	NA
Type of cancer
Breast cancer	2	1.048 (0.756-1.454)	0.778	50.1	0.699 (0.341-1.433)	0.328	63.5	0.961 (0.658-1.404)	0.838	63.9	0.795 (0.616-1.025)	0.077	42.4	0.899 (0.665-1.215)	0.488	66.1
Hepatocellular carcinoma	2	1.098 (0.851-1.415)	0.472	0	1.209 (0.913-1.599)	0.185	0	1.135 (0.893-1.442)	0.302	0	1.127 (0.947-1.341)	0.177	0	1.102 (0.972-1.250)	0.129	0
Thyroid caner	1	1.409 (1.068-1.859)	0.015	NA	1.884 (1.297-2.738)	0.001	NA	1.517 (1.167-1.972)	0.002	NA	1.542 (1.102-2.158)	0.012	NA	1.376 (1.150-1.645)	<0.001	NA
Source of controls
HB	2	1.098 (0.852-1.415)	0.471	0	1.209 (0.913-1.599)	0.185	0	1.135 (0.893-1.442)	0.302	0	1.127 (0.947-1.341)	0.177	0	1.102 (0.972-1.250)	0.129	0
PB	3	1.193 (1.028-1.385)	0.02	49.3	0.988 (0.501-1.945)	0.971	85.9	1.125 (0.815-1.552)	0.474	75.3	0.925 (0.528-1.623)	0.787	82.3	1.038 (0.777-1.388)	0.8	84.5
rs1790349 (A/G)	3	1.060 (0.850-1.323)	0.605	52	1.056 (0.793-1.407)	0.71	0	1.043 (0.837-1.300)	0.705	55.1	0.998 (0.754-1.319)	0.986	0	1.048 (0.942-1.167)	0.391	45.7
Ethnicity
Caucasian	2	1.201 (1.008-1.431)	0.04	0	1.094 (0.784-1.526)	0.598	44	1.180 (0.998-1.396)	0.053	21.2	1.003 (0.727-1.386)	0.983	30.6	1.110 (0.972-1.266)	0.122	37.4
Mixed	1	0.920 (0.739-1.145)	0.453	NA	0.957 (0.545-1.677)	0.877	NA	0.923 (0.748-1.140)	0.458	NA	0.980 (0.561-1.712)	0.944	NA	0.940 (0.783-1.128)	0.505	NA

Note: OR: odds ratio; CI: confidence interval. The results are in bold if .