Fibrinogen Level Predicts Outcomes in Critically Ill Patients with Acute Exacerbation of Chronic Heart Failure

Table 3

Subgroup analysis of the associations between fibrinogen and 90-day mortality.

Subgroup		HR (95% CI); <284 mg/dl	HR (95% CI); ≥284 mg/dl	for interaction
Gender				0.198
Male	235	Ref	4.70 (2.30-9.57)
Female	319		2.60 (1.50-4.53)
Age				0.030
<65	149	Ref	1.29 (0.50-3.28)
≥65	405		4.16 (2.51-6.88)
HBP				0.066
Yes	265	Ref	5.42 (2.55-11.51)
No	289		2.29 (1.34-3.91)
DM				0.116
Yes	224	Ref	2.21 (1.16-4.21)
No	330		4.46 (2.46-8.09)
Af				0.388
Yes	291	Ref	3.97 (2.23-7.09)
No	263		2.68 (1.38-5.20)
Respiratory failure				0.346
Yes	185	Ref	2.16 (1.14-4.11)
No	369		3.28 (1.80-5.97)
CKD				0.001
Yes	273	Ref	1.61 (0.97-2.67)
No	281		9.87 (3.91-24.8)
AKI
Yes	512	Ref	3.36 (2.17-5.20)
No	42		NA
NSTEMI				0.992
Yes	131	Ref	3.31 (1.27-8.63)
No	423		3.35 (2.05-5.46)
STEMI				0.161
Yes	32	Ref	1.12 (0.23-5.30)
No	522		3.53 (2.24-5.56)
Vasopressor use				0.304
Yes	403	Ref	3.81 (2.31-6.30)
No	151		2.29 (0.94-5.54)
Ventilator use				0.085
Yes	427	Ref	4.00 (2.43-6.60)
No	127		1.63 (0.67-3.94)
CRRT use				0.111
Yes	41	Ref	1.59 (0.64-3.96)
No	513		3.63 (2.21-5.98)
SOFA scores				0.293
<6	234	Ref	4.95 (2.11-11.60)
≥6	320		2.86 (1.71-4.79)
APS III scores				0.023
<48	271	Ref	7.69 (2.69-21.9)
≥48	283		1.96 (1.21-3.17)
SAPS II scores				0.966
<42	271	Ref	3.16 (1.44-6.94)
≥42	283		3.05 (1.80-5.15)
SIRS scores				0.845
<3	150	Ref	3.57 (1.45-8.78)
≥3	404		3.20 (1.94-5.26)