H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Figure 6

Effects of DSS, MSC, and MSC-H19 on the inflammatory response were measured by the detection of mRNA levels of TNF-α, IL-1, IL-6, and IL-8 ( value <0.05 vs. control; value <0.05 vs. DSS; # value <0.05 vs. DDS + MSC). (a) Level of TNF-α mRNA in mice was the highest and lowest, respectively, in the DSS and SHAM groups. (b) Level of IL-1 mRNA in mice was the highest and lowest, respectively, in the DSS and SHAM groups. (c) Level of IL-6 mRNA in mice was the highest and lowest, respectively, in the DSS and SHAM groups. (d) Level of IL-8 mRNA in mice was the highest and lowest, respectively, in the DSS and SHAM groups.

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