H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Figure 7

Effects of DSS, MSC, and MSC-H19 on miR-141, ICAM-1 mRNA, miR-139, and CXCR4 levels ( value <0.05 vs. control; value <0.05 vs. DSS). (a) RNA level of miR-141 in mice was the highest in the DSS group and the lowest in the SHAM group. (b) RNA level of ICAM-1 in mice was the highest and lowest, respectively, in the SHAM and DSS groups. (c) RNA level of miR-139 in mice was the highest in the DSS group and the lowest in the SHAM group. (d) RNA level of CXCR4 in mice was the highest and lowest, respectively, in the SHAM and DSS groups. (e) Protein level of ICAM-1 in mice was the highest and lowest, respectively, in the SHAM and DSS groups. (f) Protein level of CRCX4 in mice was the highest and lowest, respectively, in the SHAM and DSS groups.

(a)

(b)

(c)

(d)

(e)

(f)