Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Table 2

Comparative characteristics of patients with different degrees of lung damage on admission.

	CT0, 1	CT2	CT3,4	^Kruskal-Wallis
	26	16	14
Age, y	64.5 [51.3; 71.8]	60.5 [52.8; 67.5]	56.0 [49.3; 62.8]
Sex, man (%)	18 (72%)	11 (69%)	14 (100%)^‡
Arterial hypertension (%)	13 (23%)	6 (11%)	5 (9%)
Diabetes mellitus (%)	3 (12%)	2 (11%)	2 (13%)
Atherosclerosis (%)	9 (36%)	3 (16%)	4 (29%)
SpO2, %	97 [95; 98]	96 [94; 97.3]	97 [96; 98]
HGB, g/l	140 [128; 161]	130 [119; 161]	147 [144; 149]
HCT, %	42 [37; 45]	43 [36; 47]	43 [42; 43]
RBC, 10^12/l	5.0 [4.3; 5.2]	5.0 [3.6; 5.4]	4.9 [4.5; 5.1]
PLT, 10^9/l	261 [216; 326]	237 [163; 275]	253 [210; 304]
MCV, fl	85.5 [82.5; 88.0]	87 [85; 90]	86.5 [84; 91.1]
MCH, pg/cell	30 [28.3; 30.2]	30.5 [28.2; 31.7]	29.6 [29.0; 30.0]
MCHC, g/l	348 [335; 360]	343 [329; 362]	347 [335; 354]
WBC, 10^9/l	6.14 [4.68; 8.88]	5.2 [3.7; 5.9]	7.7 [4.4; 10.9]
LI	2.4 [1.8; 3.4]	2.9 [1.7; 4.5]	3.6 [3.2; 5.7]
ESR, mm/h	34 [19; 52]	44 [18; 71]	82 [76; 86] ^‡£
ALT, U/l	28 [20; 37.5]	30.5 [21.5; 54.5]	47.5 [29.3; 142.3]^‡
AST, U/l	29.5 [26.8; 35.4]	29.0 [24.5; 53.3]	50.5 [37.8; 101.5]^‡£	0.012
D-dimer, mg/l	0.93 [0.51; 1.53]	0.71 [0.46; 0.82]	1.18 [0.72; 1.69]
CRP, mg/l	7.4 [1.8; 24.0]	32.0 [6.1; 64.8]^‡	71.8 [27.0; 118.5]^‡	0.003
IL-6, ng/l	4.85 [3.00; 18.5]	6.40 [4.39; 16.0]	14.06 [9.47; 66.40]^‡
Ferritin, ng/ml	226.5 [80; 324.5]	295 [211; 345]	358 [277; 764]
Creatinine, μM	90.5 [78; 101.8]	95.5 [86.3; 134]	98 [85.1; 122.5]
GSH, μM	1.81 [1.04; 2.34]	1.15 [0.86; 1.76]	1.22 [0.76; 1.42]^‡
Hcy, μM	7.4 [5.9; 9.3]	8.3 [7.0; 10.5]	9.1 [6.5; 12.8]
SAM, nM	59 [48; 72]	57 [51; 84]	84 [64, 115]^‡
SAH, nM	14.4 [4.4; 19.9]	10.2 [8.0; 18.3]	14.5 [12.2; 24.7]
SAM/SAH	3.6 [2.7; 5.4]	7.2 [4.2; 9.1]^‡	5.5 [3.3; 9.3]
SAM/GSH, nM/μM	32 [23; 52]	57 [36; 131]^‡	60 [42; 285]^‡	0.017

^‡ compared with “CT0,1” group. ^£ compared with “CT2” group. ALT: alanine aminotransferase; AST: aspartate aminotransferase; CRB: C-reactive protein; CT: computed tomography; ESR: the erythrocyte sedimentation rate; GSH: glutathione; HCT: hematocrit; Hcy: homocysteine; HGB: hemoglobin; IL-6: interleukin-6; LI: leukocyte index; MCH: mean erythrocyte hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean erythrocyte volume; PLT: platelets; RBC: red blood cells; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine; SpO₂: oxygenation of blood; WBC: white blood cells.